Sphincter of Oddi botulinum toxin injection to prevent pancreatic fistula after distal pancreatectomy

Postoperative pancreatic fistula represents the most important complication after distal pancreatectomy. The aim of this study was to evaluate the use of a preoperative endoscopic injection of botulinum toxin into the sphincter of Oddi to prevent postoperative pancreatic fistula (German Clinical Trials Register number: DRKS00007885).This was an investigator-initiated, prospective clinical phase I/II trial with an exploratory study design. We...