Original paper
Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor
Abstract
Apoptosis-inducing factor (AIF) is critical for mitochondrial respiratory complex biogenesis and for mediating necroptotic parthanatos; these functions are seemingly regulated by enigmatic allosteric switching driven by NADH charge-transfer complex (CTC) formation. Here, we define molecular pathways linking AIF's active site to allosteric switching regions by characterizing dimer-permissive mutants using small-angle X-ray scattering (SAXS) and...
Paper Details
Title
Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor
Published Date
Dec 1, 2016
Journal
Volume
24
Issue
12
Pages
2067 - 2079
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Notes
History