Original paper

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas

Cell45.50
Volume: 167, Issue: 5, Pages: 1264 - 1280.e18
Published: Nov 1, 2016
Abstract
Granulomas are immune cell aggregates formed in response to persistent inflammatory stimuli. Granuloma macrophage subsets are diverse and carry varying copy numbers of their genomic information. The molecular programs that control the differentiation of such macrophage populations in response to a chronic stimulus, though critical for disease outcome, have not been defined. Here, we delineate a macrophage differentiation pathway by which a...
Paper Details
Title
DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas
Published Date
Nov 1, 2016
Journal
Volume
167
Issue
5
Pages
1264 - 1280.e18
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