Toward a Comprehensive Clinical Staging Model for Bipolar Disorder: Integrating the Evidence

Objectives: To describe key findings relating to the natural history and heterogeneity of bipolar disorder (BD) relevant to the development of a unitary clinical staging model. Currently proposed staging models are briefly discussed, highlighting complementary findings, and a comprehensive staging model of BD is proposed integrating the relevant evidence. Method: A selective review of key published findings addressing the natural history,...