Synthesis, structural elucidation and biological activities of organotin(IV) derivatives of 4-(2-thienyl)butyric acid

Published on Feb 1, 2017in Journal of The Iranian Chemical Society1.74
· DOI :10.1007/s13738-016-0987-7
Farzana Shaheen2
Estimated H-index: 2
(Allama Iqbal Open University),
Muhammad Sirajuddin15
Estimated H-index: 15
(University of Science and Technology)
+ 4 AuthorsKhadija Shahid3
Estimated H-index: 3
(Riphah International University)
A series of tri- and diorganotin(IV) derivatives of 4-(2-thienyl)butyric acid have been synthesized by the reaction of ligand acid with tri- and diorganotin salts in 1:1 and 2:1 molar ratios, respectively. The synthesized compounds have been confirmed by CHNS elemental analyses, FTIR, multinuclear NMR (1H and 13C) spectroscopy and X-ray diffraction studies. NMR data reveal a 5-coordinate geometry for the triorganotin(IV) derivatives, while 6-coordinate for the diorganotin(IV) derivatives, respectively. The X-ray crystallographic analysis of the compound 2 showed polymeric 5-coordinate trigonal bipyramidal geometry. Antimicrobial studies were also evaluated against different strains of bacteria (Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis and Staphylococcus aureus) and fungi (Mucor species, Aspergillus solani, Helminthosporium oryzae, Aspergillus flavus, Aspergillus niger) to establish the biological significance of these compounds. The synthesized compounds probably work by interfering with the ability of bacteria to form cell walls by keeping unwanted substances from entering their cells and stop the contents of their cells from leaking out due which the bacteria get die. The antifungal activity of some of the tested compound is comparable to that of the standard drug, terbinafine. From their antimicrobial results, it was concluded that they might be used as potential candidate for the generation of new antimicrobial drugs.
  • References (15)
  • Citations (2)
#1Muhammad Sirajuddin (QAU: Quaid-i-Azam University)H-Index: 15
#2Saqib Ali (QAU: Quaid-i-Azam University)H-Index: 30
Last.Hammad Pasha (QAU: Quaid-i-Azam University)H-Index: 1
view all 5 authors...
#1Muhammad Sirajuddin (CUI: COMSATS Institute of Information Technology)H-Index: 15
#2Saqib Ali (QAU: Quaid-i-Azam University)H-Index: 30
Last.Jamshad Iqbal (CUI: COMSATS Institute of Information Technology)H-Index: 2
view all 5 authors...
#1Saghir Abbas (QAU: Quaid-i-Azam University)H-Index: 4
#2Mukhtiar Hussain (QAU: Quaid-i-Azam University)H-Index: 11
Last.Jamshed Iqbal (CUI: COMSATS Institute of Information Technology)H-Index: 26
view all 7 authors...
#1Shuqiang Niu (WSU: Washington State University)H-Index: 9
#2Guang Ming LiH-Index: 6
Last.Toshiko Ichiye (WSU: Washington State University)H-Index: 25
view all 5 authors...
Cited By2
#1S. Khalid (QAU: Quaid-i-Azam University)
#2F. Shaheen (Allama Iqbal Open University)
Last.Saqib Ali (QAU: Quaid-i-Azam University)H-Index: 30
view all 3 authors...
View next paperDi‐ and Triorganotin(IV) Esters of 3,4‐Methylenedioxyphenylpropenoic Acid: Synthesis, Spectroscopic Characterization and Biological Screening for Antimicrobial, Cytotoxic and Antitumor Activities