Review paper
The Chromatin Landscape of Cellular Senescence
Abstract
Cellular senescence, an irreversible growth arrest triggered by a variety of stressors, plays important roles in normal physiology and tumor suppression, but accumulation of senescent cells with age contributes to the functional decline of tissues. Senescent cells undergo dramatic alterations to their chromatin landscape that affect genome accessibility and their transcriptional program. These include the loss of DNA-nuclear lamina interactions,...
Paper Details
Title
The Chromatin Landscape of Cellular Senescence
Published Date
Nov 1, 2016
Journal
Volume
32
Issue
11
Pages
751 - 761
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