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Yee Voan Teo
Brown University
Molecular biologyNotch signaling pathwaySenescenceBiologyCell biology
7Publications
3H-index
58Citations
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Publications 7
Newest
#1Stephany Foster (Brown University)
#2Yee Voan Teo (Brown University)H-Index: 3
Last. Gary M. Wessel (Brown University)H-Index: 42
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#1Yee Voan Teo (Brown University)H-Index: 3
#2Nattaphong Rattanavirotkul (Edin.: University of Edinburgh)H-Index: 1
Last. Tamir Chandra (Edin.: University of Edinburgh)H-Index: 17
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Summary Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints. Using single-cell analysis, we observed two distinct transcriptional endpoints, a primary endpoint marked by Ras and a secondary endpoint marked by Notch activation. We find t...
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#1Yee Voan Teo (Brown University)H-Index: 3
#2Nattaphong Rattanavirotkul (Edin.: University of Edinburgh)H-Index: 1
Last. Tamir Chandra (Edin.: University of Edinburgh)H-Index: 17
view all 14 authors...
Oncogene induced senescence (OIS) is a tumour suppressive response to oncogene activation that can be transmitted to neighbouring cells through secreted factors of the senescence associated secretory phenotype (SASP). Using single-cell transcriptomics we observed two distinct endpoints, a primary marked by Ras and a secondary by Notch. We find that secondary senescence in vitro and in vivo requires Notch, rather than SASP alone as previously thought. Currently, primary and secondary senescent ce...
Source
#1Yee Voan Teo (Brown University)H-Index: 3
#2Miriam Capri (UNIBO: University of Bologna)H-Index: 46
Last. Nicola Neretti (Brown University)H-Index: 24
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7 CitationsSource
#1Takahiro Ito (Brown University)H-Index: 10
#2Yee Voan Teo (Brown University)H-Index: 3
Last. John M. Sedivy (Brown University)H-Index: 65
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Summary Polycomb group (PcG) factors maintain facultative heterochromatin and mediate many important developmental and differentiation processes. EZH2, a PcG histone H3 lysine-27 methyltransferase, is repressed in senescent cells. We show here that downregulation of EZH2 promotes senescence through two distinct mechanisms. First, depletion of EZH2 in proliferating cells rapidly initiates a DNA damage response prior to a reduction in the levels of H3K27me3 marks. Second, the eventual loss of H3K2...
19 CitationsSource
#1Steven W. Criscione (Brown University)H-Index: 9
#2Yee Voan Teo (Brown University)H-Index: 3
Last. Nicola Neretti (Brown University)H-Index: 24
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Cellular senescence, an irreversible growth arrest triggered by a variety of stressors, plays important roles in normal physiology and tumor suppression, but accumulation of senescent cells with age contributes to the functional decline of tissues. Senescent cells undergo dramatic alterations to their chromatin landscape that affect genome accessibility and their transcriptional program. These include the loss of DNA–nuclear lamina interactions, the distension of centromeres, and changes in chro...
30 CitationsSource
#1Yee Voan Teo (Brown University)H-Index: 3
#2Nicola Neretti (Brown University)H-Index: 24
Many metagenomics classification tools have been developed with the rapid growth of the metagenomics field. However, the classification of closely related species remains a challenge for this field. Here, we compared MetaPhlAn2, kallisto and Kraken for their performances in two metagenomics settings, human metagenomics and environmental metagenomics. Our comparative study showed that kallisto demonstrated higher sensitivity than MetaPhlAn2 and Kraken and better quantification accuracy than Krake...
2 CitationsSource
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