Unstable B7-H4 cell surface expression and T-cell redirection as a means of cancer therapy
Abstract
Tumor immune regulation has been demonstrated in clinical studies using antibodies targeted to the B7/CD28 family. B7 homolog 4 (B7-H4) negatively regulates immune responses and is overexpressed in many types of human cancer, indicating that B7-H4 may be a potential target of cancer therapy. B7-H4 expression is affected by the microenvironment, and its presence has been reported in cancer tissues and immune cells. We found an upregulation of...
Paper Details
Title
Unstable B7-H4 cell surface expression and T-cell redirection as a means of cancer therapy
Published Date
Sep 12, 2016
Journal
Volume
36
Issue
5
Pages
2625 - 2632
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