Original paper
Chronic atrial ionic remodeling by aldosterone: potentiation of L-type Ca2+ channels and its arrhythmogenic significance
Volume: 468, Issue: 11-12, Pages: 1823 - 1835
Published: Sep 15, 2016
Abstract
It is widely accepted that aldosterone induces atrial fibrillation (AF) by promoting structural changes, but its effects on the function of primary atrial myocytes remain unknown. We have investigated this point in adult rat atrial myocytes, chronically exposed to the hormone. This treatment produced larger amplitude of Ca2+ transients, longer action potential (AP) duration, and higher incidence of unsynchronized Ca2+ oscillations. Moreover, it...
Paper Details
Title
Chronic atrial ionic remodeling by aldosterone: potentiation of L-type Ca2+ channels and its arrhythmogenic significance
Published Date
Sep 15, 2016
Volume
468
Issue
11-12
Pages
1823 - 1835
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Notes
History