Archaerhodopsin Selectively and Reversibly Silences Synaptic Transmission through Altered pH
Abstract
Tools that allow acute and selective silencing of synaptic transmission in vivo would be invaluable for understanding the synaptic basis of specific behaviors. Here, we show that presynaptic expression of the proton pump archaerhodopsin enables robust, selective, and reversible optogenetic synaptic silencing with rapid onset and offset. Two-photon fluorescence imaging revealed that this effect is accompanied by a transient increase in pH...
Paper Details
Title
Archaerhodopsin Selectively and Reversibly Silences Synaptic Transmission through Altered pH
Published Date
Aug 1, 2016
Journal
Volume
16
Issue
8
Pages
2259 - 2268
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