Insulin access to skeletal muscle is impaired during the early stages of diet‐induced obesity

Objective Insulin must move from the blood to the interstitium to initiate signaling, yet access to the interstitium may be impaired in cases of insulin resistance, such as obesity. This study investigated whether consuming a short‐ and long‐term high‐fat diet (HFD) impairs insulin access to skeletal muscle, the major site of insulin‐mediated glucose uptake. Methods Male mongrel dogs were divided into three groups consisting of control diet ( n...