Histones link inflammation and thrombosis through the induction of Weibel–Palade body exocytosis

Essentials•Dysregulated DNA and histone release can promote pathological immunothrombosis.•Weibel‐Palade bodies (WPBs) are sentinel‐like organelles that respond to proinflammatory stimuli.•Histones induce WPB exocytosis in a caspase, calcium and charge‐dependent mechanism.•A targetable axis may exist between DNA/histones and WPBs in inflammation and immunothrombosis.Summary: BackgroundDamage‐associated molecular patterns (DAMPs), including...