Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks
Abstract
DNA polymerase theta (Pol θ)-mediated end joining (TMEJ) has been implicated in the repair of chromosome breaks, but its cellular mechanism and role relative to canonical repair pathways are poorly understood. We show that it accounts for most repairs associated with microhomologies and is made efficient by coupling a microhomology search to removal of non-homologous tails and microhomology-primed synthesis across broken ends. In contrast to...
Paper Details
Title
Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks
Published Date
Aug 1, 2016
Journal
Volume
63
Issue
4
Pages
662 - 673
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