Propofol administration reduces hippocampal neuronal damage induced by kainic acid in rats
Abstract
The goal of this study was to determine whether propofol has protective effect against kainic acid (KA)-induced excitotoxicity. Administration of propofol (25 mg kg-1 i.p.) was done 2 h before KA (10 mg kg-1 i.p.), immediately after, and 2 h, 4 h, 6 h, and 12 h after the KA, and twice daily for an additional three days. Neuronal cell death in CA1 and CA3 subsector of hippocampus was evaluated quantitatively four days after KA. The KA and...
Paper Details
Title
Propofol administration reduces hippocampal neuronal damage induced by kainic acid in rats
Published Date
Mar 1, 1999
Journal
Volume
21
Issue
2
Pages
225 - 228
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