Original paper

Ca2+ permeation through Na+ channels in guinea pig ventricular myocytes

Volume: 273, Issue: 1, Pages: H128 - H137
Published: Jul 1, 1997
Abstract
This study was undertaken to test the hypothesis that, in the absence of extracellular Na+, Ca2+ can permeate tetrodotoxin (TTX)-sensitive Na+ channels in Cs(+)-loaded whole cell voltage-clamped guinea pig ventricular myocytes (22-24 degrees C). With 10 mM extracellular Ca2+, 50-ms step depolarizations (-50 to +25 mV) from holding potentials of -100 or -80 mV elicited fast and slow types of inward current: 1) a small (< 400 pA)...
Paper Details
Title
Ca2+ permeation through Na+ channels in guinea pig ventricular myocytes
Published Date
Jul 1, 1997
Volume
273
Issue
1
Pages
H128 - H137
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