The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
Abstract
Identification of positive regulators of T-cell immunity induced during autoimmune diseases is critical for developing novel therapies. The endoplasmic reticulum resident ubiquitin ligase Hrd1 has recently emerged as a critical regulator of dendritic cell antigen presentation, but its role in T-cell immunity is unknown. Here we show that genetic deletion of Hrd1 in mice inhibits T-cell proliferation, production of IL-2, and differentiation of...
Paper Details
Title
The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
Published Date
Jul 15, 2016
Journal
Volume
7
Issue
1
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