Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense
Abstract
Macrophages tightly scale their core metabolism after being activated, but the precise regulation of the mitochondrial electron-transport chain (ETC) and its functional implications are currently unknown. Here we found that recognition of live bacteria by macrophages transiently decreased assembly of the ETC complex I (CI) and CI-containing super-complexes and switched the relative contributions of CI and CII to mitochondrial respiration. This...
Paper Details
Title
Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense
Published Date
Jun 27, 2016
Journal
Volume
17
Issue
9
Pages
1037 - 1045
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