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Rebeca Acín-Pérez
Centro Nacional de Investigaciones Cardiovasculares
Molecular biologyMitochondrial DNAMitochondrionBiologyCell biology
57Publications
30H-index
3,752Citations
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Publications 59
Newest
Abstract This review focuses on three independent and complementary approaches to obtain information on the combined function of respiratory complexes when present in different structural situations, either as individual complexes or when superassembled with other complexes. We review the utility of in-gel activity after blue native electrophoresis, integrated oxygen consumption of supercomplexes containing complex IV, and spectrophotometric activity measurements.
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#1Enrique Calvo (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 33
#2Sara Cogliati (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 9
Last. José Antonio Enríquez (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 50
view all 14 authors...
Mitochondrial respiratory complexes assemble into different forms of supercomplexes (SC). In particular, SC III2+IV require the SCAF1 protein. However, the structural role of this factor in the formation of the respirasome (I+III2+IV) and the physiological role of SCs are controversial. Here, we study C57BL/6J mice harbouring either non-functional SCAF1, the full knock-out for SCAF1 or the wild-type version of the protein, and found a growth and exercise phenotype due to the lack of functional S...
1 CitationsSource
#1Jesús Gómez-Escudero (Lond: University of London)H-Index: 2
#1Jesús Gómez-Escudero (Lond: University of London)H-Index: 1
Last. Alicia G. Arroyo (CSIC: Spanish National Research Council)H-Index: 30
view all 9 authors...
Angiogenesis, the formation of new blood vessels from pre-existing ones, occurs in pathophysiological contexts such as wound healing, cancer, and chronic inflammatory disease. During sprouting angiogenesis, endothelial tip and stalk cells coordinately remodel their cell-cell junctions to allow collective migration and extension of the sprout while maintaining barrier integrity. All these processes require energy, and the predominant ATP generation route in endothelial cells is glycolysis. Howeve...
1 CitationsSource
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#2Elena RamosH-Index: 6
Last. Antonio Martínez-RuizH-Index: 31
view all 22 authors...
Reactive oxygen species (ROS) generated by mitochondria are a well-known example of mitochondria-derived signals that can drive cell adaptations or trigger cell damage. This is the case of the increase in ROS upon acute hypoxia. However, the precise mechanism by which acute hypoxia triggers mitochondrial ROS production is still unknown. Mitochondrial Ca2+ movements have been considered direct effectors in cell signalling, and recent reports show that the mitochondrial Na+/Ca2+ exchanger (NCLX) h...
1 CitationsSource
#1Daniel Torralba (UAM: Autonomous University of Madrid)H-Index: 3
#2Francesc Baixauli (MPG: Max Planck Society)H-Index: 4
Last. Francisco Sánchez-Madrid (UAM: Autonomous University of Madrid)H-Index: 91
view all 16 authors...
Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate anti-pathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic...
24 CitationsSource
#1Nuria Matesanz (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 4
#2Ivana Nikolic (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 2
Last. Guadalupe Sabio (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 24
view all 22 authors...
Adipose tissue has emerged as an important regulator of whole-body metabolism, and its capacity to dissipate energy in the form of heat has acquired a special relevance in recent years as potential treatment for obesity. In this context, the p38MAPK pathway has arisen as a key player in the thermogenic program because it is required for the activation of brown adipose tissue (BAT) thermogenesis and participates also in the transformation of white adipose tissue (WAT) into BAT-like depot called b...
2 CitationsSource
#1Pablo Hernansanz-Agustín (CSIC: Spanish National Research Council)H-Index: 9
#2Elena RamosH-Index: 6
Last. Antonio Martínez-RuizH-Index: 31
view all 22 authors...
Reactive oxygen species (ROS) generated by mitochondria in acute hypoxia are a well-known example of mitochondria-derived signals that can drive cell adaptations. However, the precise mechanism by which they are produced is still unknown. Mitochondrial Ca2+ movements have been considered direct effectors in cell signaling; but the role ascribed so far to mitochondrial Na+ is to serve as a mere mediator to equilibrate membrane potential. Here we show that the mitochondrial Na+/Ca2+ exchanger (NCL...
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#1Rebeca Acín-Pérez (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 30
#2Ana Victoria Lechuga-Vieco (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 9
Last. José Antonio Enríquez (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 50
view all 16 authors...
Heart failure (HF) is a major health and economic burden in developed countries. It has been proposed that the pathogenesis of HF may involve the action of mitochondria. We evaluate three different mouse models of HF: tachycardiomyopathy, HF with preserved left ventricular (LV) ejection fraction (LVEF), and LV myocardial ischemia and hypertrophy. Regardless of whether LVEF is preserved, our results indicate that the three models share common features: an increase in mitochondrial reactive oxygen...
11 CitationsSource
#2María Villalba-Orero (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 3
Last. Enrique Lara-PezziH-Index: 31
view all 13 authors...
Abstract Background In response to pressure overload, the heart develops ventricular hypertrophy that progressively decompensates and leads to heart failure. This pathological hypertrophy is mediated, among others, by the phosphatase calcineurin and is characterized by metabolic changes that impair energy production by mitochondria. Objectives The authors aimed to determine the role of the calcineurin splicing variant CnAβ1 in the context of cardiac hypertrophy and its mechanism of action. Metho...
7 CitationsSource
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