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Rebeca Acín-Pérez
Centro Nacional de Investigaciones Cardiovasculares
54Publications
30H-index
3,473Citations
Publications 54
Newest
Published on Dec 1, 2018in Nature Communications11.88
Daniel Torralba3
Estimated H-index: 3
(UAM: Autonomous University of Madrid),
Francesc Baixauli2
Estimated H-index: 2
(MPG: Max Planck Society)
+ 13 AuthorsInmaculada Jorge16
Estimated H-index: 16
Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate anti-pathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic...
Published on May 1, 2018in Free Radical Biology and Medicine5.66
Pablo Hernansanz-Agustín9
Estimated H-index: 9
,
Elena Ramos6
Estimated H-index: 6
+ 19 AuthorsAna Cortés (Pablo de Olavide University)
Reactive oxygen species (ROS) generated by mitochondria in acute hypoxia are a well-known example of mitochondria-derived signals that can drive cell adaptations. However, the precise mechanism by which they are produced is still unknown. Mitochondrial Ca 2 + movements have been considered direct effectors in cell signaling; but the role ascribed so far to mitochondrial Na + is to serve as a mere mediator to equilibrate membrane potential. Here we show that the mitochondrial Na + /Ca 2 + exchang...
Published on Jul 6, 2018in PLOS Biology
Nuria Matesanz4
Estimated H-index: 4
(Centro Nacional de Investigaciones Cardiovasculares),
Ivana Nikolic2
Estimated H-index: 2
(Centro Nacional de Investigaciones Cardiovasculares)
+ 19 AuthorsDaniel Beiroa8
Estimated H-index: 8
(Ciber)
Adipose tissue has emerged as an important regulator of whole-body metabolism, and its capacity to dissipate energy in the form of heat has acquired a special relevance in recent years as potential treatment for obesity. In this context, the p38MAPK pathway has arisen as a key player in the thermogenic program because it is required for the activation of brown adipose tissue (BAT) thermogenesis and participates also in the transformation of white adipose tissue (WAT) into BAT-like depot called b...
Published on Mar 28, 2018in Science Translational Medicine17.16
Rebeca Acín-Pérez30
Estimated H-index: 30
(Centro Nacional de Investigaciones Cardiovasculares),
Ana V. Lechuga-Vieco8
Estimated H-index: 8
(Centro Nacional de Investigaciones Cardiovasculares)
+ 13 AuthorsCristiane Benincá1
Estimated H-index: 1
(Centro Nacional de Investigaciones Cardiovasculares)
Heart failure (HF) is a major health and economic burden in developed countries. It has been proposed that the pathogenesis of HF may involve the action of mitochondria. We evaluate three different mouse models of HF: tachycardiomyopathy, HF with preserved left ventricular (LV) ejection fraction (LVEF), and LV myocardial ischemia and hypertrophy. Regardless of whether LVEF is preserved, our results indicate that the three models share common features: an increase in mitochondrial reactive oxygen...
Published on Feb 1, 2018in Journal of the American College of Cardiology18.64
Laura Padrón-Barthe7
Estimated H-index: 7
,
María Villalba-Orero2
Estimated H-index: 2
(Centro Nacional de Investigaciones Cardiovasculares)
+ 10 AuthorsPablo García-Pavía21
Estimated H-index: 21
Abstract Background In response to pressure overload, the heart develops ventricular hypertrophy that progressively decompensates and leads to heart failure. This pathological hypertrophy is mediated, among others, by the phosphatase calcineurin and is characterized by metabolic changes that impair energy production by mitochondria. Objectives The authors aimed to determine the role of the calcineurin splicing variant CnAβ1 in the context of cardiac hypertrophy and its mechanism of action. Metho...
Published on Dec 1, 2017in Nature Communications11.88
Nuria Matesanz4
Estimated H-index: 4
(Centro Nacional de Investigaciones Cardiovasculares),
Edgar Bernardo3
Estimated H-index: 3
(Centro Nacional de Investigaciones Cardiovasculares)
+ 17 AuthorsLuis Leiva-Vega2
Estimated H-index: 2
(Centro Nacional de Investigaciones Cardiovasculares)
Increasing the thermogenic capacity of adipose tissue to enhance organismal energy expenditure is considered a promising therapeutic strategy to combat obesity. Here, we report that expression of the p38 MAPK activator MKK6 is elevated in white adipose tissue of obese individuals. Using knockout animals and shRNA, we show that Mkk6 deletion increases energy expenditure and thermogenic capacity of white adipose tissue, protecting mice against diet-induced obesity and the development of diabetes. ...
Published on Nov 15, 2017in The EMBO Journal11.23
Marta Pera2
Estimated H-index: 2
(CUMC: Columbia University Medical Center),
Delfina Larrea5
Estimated H-index: 5
(CUMC: Columbia University Medical Center)
+ 14 AuthorsMark F. Mehler52
Estimated H-index: 52
(Albert Einstein College of Medicine)
Abstract In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment (C99) that is then cleaved by γ‐secretase to generate the β‐amyloid (Aβ) found in senile plaques. In previous reports, we and others have shown that γ‐secretase activity is enriched in mitochondria‐associated endoplasmic reticulum (ER) membranes (MAM) and that ER–mitochondrial connectivity and MAM function are upregula...
Published on Oct 27, 2017in PLOS Pathogens6.46
Sara Baldanta2
Estimated H-index: 2
,
Mercedes Fernández-Escobar1
Estimated H-index: 1
+ 6 AuthorsSusana Guerra20
Estimated H-index: 20
The interferon (IFN)-stimulated gene 15 (ISG15) encodes one of the most abundant proteins induced by interferon, and its expression is associated with antiviral immunity. To identify protein components implicated in IFN and ISG15 signaling, we compared the proteomes of ISG15-/- and ISG15+/+ bone marrow derived macrophages (BMDM) after vaccinia virus (VACV) infection. The results of this analysis revealed that mitochondrial dysfunction and oxidative phosphorylation (OXPHOS) were pathways altered ...
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