Defining the consequences of genetic variation on a proteome-wide scale
Abstract
Genetic variation modulates protein expression through both transcriptional and post-transcriptional mechanisms. To characterize the consequences of natural genetic diversity on the proteome, here we combine a multiplexed, mass spectrometry-based method for protein quantification with an emerging outbred mouse model containing extensive genetic variation from eight inbred founder strains. By measuring genome-wide transcript and protein...
Paper Details
Title
Defining the consequences of genetic variation on a proteome-wide scale
Published Date
Jun 15, 2016
Journal
Volume
534
Issue
7608
Pages
500 - 505
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