Randomized Trial of a Lifestyle Program in Obese Infertile Women

Published on May 19, 2016in The New England Journal of Medicine70.67
· DOI :10.1056/NEJMoa1505297
Meike Mutsaerts8
Estimated H-index: 8
(UG: University of Groningen),
Anne M. van Oers4
Estimated H-index: 4
(UG: University of Groningen)
+ 28 AuthorsAnnemieke Hoek34
Estimated H-index: 34
(UG: University of Groningen)
BackgroundSmall lifestyle-intervention studies suggest that modest weight loss increases the chance of conception and may improve perinatal outcomes, but large randomized, controlled trials are lacking. MethodsWe randomly assigned infertile women with a body-mass index (the weight in kilograms divided by the square of the height in meters) of 29 or higher to a 6-month lifestyle intervention preceding treatment for infertility or to prompt treatment for infertility. The primary outcome was the vaginal birth of a healthy singleton at term within 24 months after randomization. ResultsWe assigned women who did not conceive naturally to one of two treatment strategies: 290 women were assigned to a 6-month lifestyle-intervention program preceding 18 months of infertility treatment (intervention group) and 287 were assigned to prompt infertility treatment for 24 months (control group). A total of 3 women withdrew consent, so 289 women in the intervention group and 285 women in the control group were included in ...
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