Conversion of a light-driven proton pump into a light-gated ion channel
Abstract
Interest in microbial rhodopsins with ion pumping activity has been revitalized in the context of optogenetics, where light-driven ion pumps are used for cell hyperpolarization and voltage sensing. We identified an opsin-encoding gene (CsR) in the genome of the arctic alga Coccomyxa subellipsoidea C-169 that can produce large photocurrents in Xenopus oocytes. We used this property to analyze the function of individual residues in proton pumping....
Paper Details
Title
Conversion of a light-driven proton pump into a light-gated ion channel
Published Date
Nov 24, 2015
Journal
Volume
5
Issue
1
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