Original paper
Transient overexpression of exogenous APOBEC3A causes C-to-U RNA editing of thousands of genes
Abstract
APOBEC3A cytidine deaminase induces site-specific C-to-U RNA editing of hundreds of genes in monocytes exposed to hypoxia and/or interferons and in pro-inflammatory macrophages. To examine the impact of APOBEC3A overexpression, we transiently expressed APOBEC3A in HEK293T cell line and performed RNA sequencing. APOBEC3A overexpression induces C-to-U editing at more than 4,200 sites in transcripts of 3,078 genes resulting in protein recoding of...
Paper Details
Title
Transient overexpression of exogenous APOBEC3A causes C-to-U RNA editing of thousands of genes
Published Date
Jun 3, 2016
Journal
Volume
14
Issue
5
Pages
603 - 610
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Notes
History