Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

Group 1 and 3 innate lymphoid cells can be functionally plastic. Humbles and colleagues find that group 2 innate lymphoid cells in the lungs also exhibit phenotypic plasticity after exposure to infectious or noxious agents. Innate lymphoid cells (ILCs) are critical mediators of mucosal immunity, and group 1 ILCs (ILC1 cells) and group 3 ILCs (ILC3 cells) have been shown to be functionally plastic. Here we found that group 2 ILCs (ILC2 cells)...