Match!

Circulating Biomarkers of Dairy Fat and Risk of Incident Diabetes Mellitus Among Men and Women in the United States in Two Large Prospective Cohorts.

Published on Apr 26, 2016in Circulation23.05
· DOI :10.1161/CIRCULATIONAHA.115.018410
Mohammad Yawar Yakoob26
Estimated H-index: 26
,
Peilin Shi30
Estimated H-index: 30
+ 5 AuthorsDariush Mozaffarian113
Estimated H-index: 113
Cite
Abstract
Background—In prospective studies, the relationship of self-reported consumption of dairy foods with risk of diabetes mellitus is inconsistent. Few studies have assessed dairy fat, using circulating biomarkers, and incident diabetes mellitus. We tested the hypothesis that circulating fatty acid biomarkers of dairy fat, 15:0, 17:0, and t-16:1n-7, are associated with lower incident diabetes mellitus. Methods and Results—Among 3333 adults aged 30 to 75 years and free of prevalent diabetes mellitus at baseline, total plasma and erythrocyte fatty acids were measured in blood collected in 1989 to 1990 (Nurses’ Health Study) and 1993 to 1994 (Health Professionals Follow-Up Study). Incident diabetes mellitus through 2010 was confirmed by a validated supplementary questionnaire based on symptoms, diagnostic tests, and medications. Risk was assessed by using Cox proportional hazards, with cohort findings combined by meta-analysis. During mean±standard deviation follow-up of 15.2±5.6 years, 277 new cases of diabetes...
  • References (34)
  • Citations (37)
Cite
References34
Newest
Published on Jun 1, 2015in The American Journal of Clinical Nutrition6.57
Jessica Smith16
Estimated H-index: 16
,
Tao Hou8
Estimated H-index: 8
+ 4 AuthorsDariush Mozaffarian113
Estimated H-index: 113
Background: Dietary guidelines recommend interchanging protein foods (e.g., chicken for red meat), but they may be exchanged for carbohydrate-rich foods varying in quality [glycemic load (GL)]. Whether such exchanges occur and how they influence long-term weight gain are not established. Objective: Our objective was to determine how changes in intake of protein foods, GL, and their interrelationship influence long-term weight gain. Design: We investigated the association between 4-y changes in c...
Published on Feb 1, 2015in The American Journal of Clinical Nutrition6.57
Dariush Mozaffarian113
Estimated H-index: 113
(Harvard University),
Edmond K. Kabagambe37
Estimated H-index: 37
+ 26 AuthorsMarguerite R. Irvin25
Estimated H-index: 25
(UAB: University of Alabama at Birmingham)
Long-chain n-3 polyunsaturated fatty acids (PUFAs) can derive from diet or from a-linolenic acid (ALA) by elongation and desaturation. We investigated the association of common genetic variation with plasma phospholipid levels of the four major n-3 PUFAs by performing genome-wide association studies in five population-based cohorts comprising 8,866 subjects of European ancestry. Minor alleles of SNPs in FADS1 and FADS2 (desaturases) were associated with higher levels of ALA (p=3610 264 ) and low...
Published on Dec 1, 2014in BMC Medicine8.29
Mu Chen10
Estimated H-index: 10
(Harvard University),
Qi Sun62
Estimated H-index: 62
(Harvard University)
+ 4 AuthorsFrank B. Hu202
Estimated H-index: 202
(Harvard University)
Background The relation between consumption of different types of dairy and risk of type 2 diabetes (T2D) remains uncertain. Therefore, we aimed to evaluate the association between total dairy and individual types of dairy consumptions and incident T2D in US adults.
Published on Dec 1, 2014in The American Journal of Clinical Nutrition6.57
Mohammad Yawar Yakoob26
Estimated H-index: 26
,
Peilin Shi30
Estimated H-index: 30
+ 5 AuthorsDariush Mozaffarian113
Estimated H-index: 113
Background: Previous observational studies of self-reported dairy product consumption and stroke risk have reported mixed findings. Few studies have used circulating biomarkers that provide objective measures of dairy fat intake. Objectives: We tested the hypothesis that the circulating biomarkers of dairy fat, pentadecanoic acid (15:0), heptadecanoic acid (17:0), and trans palmitoleate (trans 16:1n−7), were associated with lower incidence of stroke, especially ischemic stroke. Secondarily, we e...
Published on Oct 1, 2014in The Lancet Diabetes & Endocrinology24.54
Nita G. Forouhi77
Estimated H-index: 77
(University of Cambridge),
Albert Koulman5
Estimated H-index: 5
(MRC Human Nutrition Research)
+ 44 AuthorsNicholas J. Wareham162
Estimated H-index: 162
(University of Cambridge)
Summary Background Conflicting evidence exists regarding the association between saturated fatty acids (SFAs) and type 2 diabetes. In this longitudinal case-cohort study, we aimed to investigate the prospective associations between objectively measured individual plasma phospholipid SFAs and incident type 2 diabetes in EPIC-InterAct participants. Methods The EPIC-InterAct case-cohort study includes 12 403 people with incident type 2 diabetes and a representative subcohort of 16 154 individuals w...
Published on Jun 1, 2014in The American Journal of Clinical Nutrition6.57
Mario Kratz19
Estimated H-index: 19
(UW: University of Washington),
Santica M. Marcovina83
Estimated H-index: 83
(UW: University of Washington)
+ 6 AuthorsKristina M. Utzschneider33
Estimated H-index: 33
Background: Plasma phospholipid concentrations of trans-palmitoleic acid (trans-16:1n−7), a biomarker of dairy fat intake, are inversely associated with incident type 2 diabetes in 2 US cohorts. Objective: The objective was to investigate whether the intake of trans-16:1n−7 in particular, or dairy fat in general, is associated with glucose tolerance and key factors determining glucose tolerance. Design: A cross-sectional investigation was undertaken in 17 men and women with nonalcoholic fatty li...
Published on May 1, 2014in Metabolism-clinical and Experimental6.51
Kristin M. Hirahatake3
Estimated H-index: 3
(ARS: Agricultural Research Service),
Joanne L. Slavin57
Estimated H-index: 57
(UMN: University of Minnesota)
+ 1 AuthorsSean H. Adams33
Estimated H-index: 33
(UC Davis: University of California, Davis)
Abstract Epidemiological evidence supports an inverse relationship between adequate intake of dairy foods and susceptibility to type 2 diabetes (T2D). The biological mechanisms responsible for this association remain to be established. This review provides a current perspective on proposed mechanisms that may underlie these effects, and highlights how randomized clinical trials can be applied to investigate these relationships. Results from epidemiological studies generally support that consumpt...
Published on Mar 1, 2014in The American Journal of Clinical Nutrition6.57
Anke Jaudszus8
Estimated H-index: 8
(FSU: University of Jena),
Ronny Kramer8
Estimated H-index: 8
(FSU: University of Jena)
+ 3 AuthorsKatrin Kuhnt12
Estimated H-index: 12
(FSU: University of Jena)
Background: trans Palmitoleic acid (t-16:1n–7, or 16:1t 9i n thed nomenclature usually applied to trans fatty acids and used herein) arouses great scientific interest because it has been suggested to serve as a biomarker for lower risks of type 2 diabetes and coronary artery disease. Objective: Although 16:1t9 has been assumed to derive from dietary sources, we examined the hypothesis that 16:1t9 might also be endogenously produced from its metabolic precursor vaccenic acid (t-18:1n–7 or 18:1t11...
Published on Jan 1, 2014in The American Journal of Clinical Nutrition6.57
Paul J. Nestel66
Estimated H-index: 66
(Baker IDI Heart and Diabetes Institute),
Nora E. Straznicky33
Estimated H-index: 33
(Baker IDI Heart and Diabetes Institute)
+ 6 AuthorsPeter J. Meikle46
Estimated H-index: 46
(Baker IDI Heart and Diabetes Institute)
Background: Reports have suggested that the consumption of dairy foods may reduce risk of type 2 diabetes on the basis of evidence of raised circulating ruminant fatty acids. Objective: We determined whether certain phospholipid species and fatty acids that are associated with full-fat dairy consumption may also be linked to diminished insulin resistance. Design: Four variables of insulin resistance and sensitivity were defined from oral-glucose-tolerance tests in 86 overweight and obese subject...
Published on Oct 11, 2013in PLOS ONE2.78
Jocelyne Benatar9
Estimated H-index: 9
(Auckland City Hospital),
Karishma Sidhu5
Estimated H-index: 5
(Auckland City Hospital),
Ralph Stewart33
Estimated H-index: 33
(Auckland City Hospital)
Importance Clear guidelines on the health effects of dairy food are important given the high prevalence of obesity, cardiovascular disease and diabetes, and increasing global consumption of dairy food.
Cited By37
Newest
Published on 2019in Molecular metabolism6.18
Ismail Cimen (LMU: Ludwig Maximilian University of Munich), Zehra Yildirim + 7 AuthorsEbru Erbay11
Estimated H-index: 11
Abstract Objective Saturated and trans fat consumption is associated with increased cardiovascular disease (CVD) risk. Current dietary guidelines recommend low fat and significantly reduced trans fat intake. Full fat dairy can worsen dyslipidemia, but recent epidemiological studies show full-fat dairy consumption may reduce diabetes and CVD risk. This dairy paradox prompted a reassessment of the dietary guidelines. The beneficial metabolic effects in dairy have been claimed for a ruminant-derive...
Published on Jul 1, 2019in Prostaglandins Leukotrienes and Essential Fatty Acids2.86
M. Slim (McGill University), C. Ha (McGill University)+ 3 AuthorsHope A. Weiler24
Estimated H-index: 24
(McGill University)
Abstract Introduction Pentadecanoic (C15:0), heptadecanoic (C17:0) and trans-palmitoleic (t16:1n-7) fatty acids (FAs) are often used as biomarkers for dairy fat in adults. This study aimed to investigate the relationship between dairy product intake and these FAs in adolescents. Material and methods Healthy adolescents were randomized to one of three groups (Group 1: control; Group 2: consume 3 dairy servings/day; and Group 3: consume ≥ 4 servings/d). C15:0, C17:0 and t -C16:1n-7 were quantified...
Published on May 16, 2019in Nature Reviews Cardiology17.42
Jason H.Y. Wu33
Estimated H-index: 33
(The George Institute for Global Health),
Renata Micha38
Estimated H-index: 38
(Tufts University),
Dariush Mozaffarian113
Estimated H-index: 113
(Tufts University)
The effect of dietary fats on cardiometabolic diseases, including cardiovascular diseases and type 2 diabetes mellitus, has generated tremendous interest. Many earlier investigations focused on total fat and conventional fat classes (such as saturated and unsaturated fats) and their influence on a limited number of risk factors. However, dietary fats comprise heterogeneous molecules with diverse structures, and growing research in the past two decades supports correspondingly complex health effe...
Published on Sep 11, 2019in Nutrients4.17
Samuel Furse7
Estimated H-index: 7
,
Alexandre G. Torres , Albert Koulman27
Estimated H-index: 27
There is mounting evidence that the consumption of fermented dairy products such as cheese and yoghurt is associated with a reduced risk of type II diabetes. This effect is greater than in fresh milk and differs between cheese and yoghurt. However, the molecular components responsible for the effect are not known. We tested the hypothesis that the lipid and/or glyceride profiles of yoghurts and cheeses are distinct from one another and fresh milk. We developed a novel sample preparation techniqu...
Published on Mar 18, 2019in Canadian Journal of Animal Science0.85
Sergio A. Burgos2
Estimated H-index: 2
(McGill University),
Stefanie LaForce (McGill University), Xin Zhao37
Estimated H-index: 37
(McGill University)
The purpose of this review is to examine the recent literature concerning the role of dairy fat intake on cardiometabolic health, focusing on prospective cohort studies that evaluated associations ...
Published on Aug 28, 2019in Nutrients4.17
Amélie Isabelle Sylvie Sobczak2
Estimated H-index: 2
,
Claudia A. Blindauer27
Estimated H-index: 27
,
Alan J. Stewart23
Estimated H-index: 23
Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid (FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms by which the plasma FFA profile of subjects with T2DM changes is unclear, but it is thought that dietary fats and changes to lipid metabolism are likely to contribute. Therefore, establishing the changes in concentrations of specific FFAs in an individual’s plasma is important. Each type of FFA has different effects on...
Published on 2019in The American Journal of Clinical Nutrition6.57
Andres V. Ardisson Korat5
Estimated H-index: 5
(Harvard University),
Yanping Li43
Estimated H-index: 43
(Harvard University)
+ 4 AuthorsQi Sun62
Estimated H-index: 62
(Harvard University)
Published on Jan 1, 2019in Frontiers in Nutrition
Colin D. Rehm27
Estimated H-index: 27
(Albert Einstein College of Medicine),
Adam Drewnowski85
Estimated H-index: 85
(UW: University of Washington)
Abstract: Recent dietary guidelines have become more food-based, as opposed to purely nutrient-based. By contrast, modeling the impact of dietary changes on chronic disease risk continues to rely on single-nutrient substitutions. To assess the real-world implications of a nutrient-for-nutrient swap, this study examined dietary nutrient density and healthy diet scores following removal of food sources of dairy fat from diets of 15,260 individuals age >4 y in the National Health and Nutrition Exam...
Published on May 9, 2019in Journal of Nutrition4.42
Kim Kummer , Paul N. Jensen20
Estimated H-index: 20
(UW: University of Washington)
+ 4 AuthorsAmanda M. Fretts16
Estimated H-index: 16
Published on May 14, 2018in European Journal of Nutrition4.45
Khalid Iqbal8
Estimated H-index: 8
,
Lukas Schwingshackl30
Estimated H-index: 30
+ 7 AuthorsHeiner Boeing108
Estimated H-index: 108
Purpose The aim of the study was to investigate the association between the previously identified Gaussian graphical models’ (GGM) food intake networks and risk of major chronic diseases as well as intermediate biomarkers in the European Prospective Investigation into Cancer and nutrition (EPIC)-Potsdam cohort.
View next paperCirculating Biomarkers of Dairy Fat and Risk of Incident Diabetes Mellitus Among US Men and Women in Two Large Prospective Cohorts.