Development of a liquid chromatography–tandem mass spectrometry method to address the increased utilization of umbilical cord in the assessment of in utero drug exposure

The method described supports the detection of drugs and drug metabolites in the assessment of in utero drug exposure. The presented method employs liquid chromatography–tandem mass spectrometry (LC–MS/MS) as an alternative to a previously validated method using liquid chromatography-time-of-flight mass spectrometry (LC-TOF/MS). A reduction in required chromatographic time and consolidation from two injections to one injection per sample was...