Aspirin Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway

Aspirin exacerbated respiratory disease (AERD) involves overproduction of cysteinyl-leukotrienes (cysLTs), activation of airway mast cells (MCs), and bronchoconstriction in response to nonselective-cyclooxygenase inhibitors. The mechanistic basis for MC activation in this disorder is unknown, but can be inhibited by inhibition of cysLT synthesis, suggesting MC activation in AERD occurs by an idiosyncratic, cysLTs-dependent mechanism. IL-33, a...