The delivery of therapeutic oligonucleotides
Abstract
The oligonucleotide therapeutics field has seen remarkable progress over the last few years with the approval of the first antisense drug and with promising developments in late stage clinical trials using siRNA or splice switching oligonucleotides. However, effective delivery of oligonucleotides to their intracellular sites of action remains a major issue. This review will describe the biological basis of oligonucleotide delivery including the...
Paper Details
Title
The delivery of therapeutic oligonucleotides
Published Date
Apr 15, 2016
Journal
Volume
44
Issue
14
Pages
6518 - 6548
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