Abstract 5119: Quantitative proteomics of myeloid cells reveal upregulation of the Fc receptor and integrin pathways in a mouse ovarian cancer model

The tumor microenvironment exerts a profound effect on tumor growth and therapeutic response. Innate immune bone marrow derived cells (BMDCs), including tumor-associated macrophages, and myeloid-derived suppressor cells are prominent in cancer hosts, and their presence correlates with poor prognosis for many human cancers. Here, we examine the role of BMDCs in a mouse model for advanced ovarian cancer. Ovarian cancer is the 5th leading cause of...