Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces
Abstract
Recently it has been shown that cancer mutations selectively target protein-protein interactions. We hypothesized that mutations affecting distinct protein interactions involving established cancer genes could contribute to tumor heterogeneity, and that novel mechanistic insights might be gained into tumorigenesis by investigating protein interactions under positive selection in cancer. To identify protein interactions under positive selection...
Paper Details
Title
Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces
Published Date
Apr 4, 2016
Journal
Volume
11
Issue
4
Pages
e0152929 - e0152929
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