Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells
Abstract
Promiscuous expression of tissue restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is crucial for negative selection of self-reactive T cells to establish central tolerance. Intercellular transfer of self-peptide-MHC complexes from mTECs to thymic dendritic cells (DCs) allows DCs to acquire TRAs, which in turn contributes to negative selection and regulatory T cell generation. However, mTECs are unlikely to express all...
Paper Details
Title
Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells
Published Date
Mar 29, 2016
Journal
Volume
11
Issue
3
Pages
e0152641 - e0152641
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