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Hongxia Wang
Duke University
ImmunologyT cellPI3K/AKT/mTOR pathwayBiologyCell biology
10Publications
6H-index
120Citations
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Publications 11
Newest
#1Jialong Yang (Duke University)H-Index: 24
#2Hongxia Wang (Duke University)H-Index: 6
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 7 authors...
CD4+ T helper (TH) cells are critical for protective adaptive immunity against pathogens, and they also contribute to the pathogenesis of autoimmune diseases. How TH differentiation is regulated by the TCR’s downstream signaling is still poorly understood. We describe here that diacylglycerol kinases (DGKs), which are enzymes that convert diacylglycerol (DAG) to phosphatidic acid, exert differential effects on TH cell differentiation in a DGK dosage-dependent manner. A deficiency of either DGKa ...
Source
#1Xingguang LinH-Index: 4
#2Jialong YangH-Index: 24
Last. Xiao-Ping ZhongH-Index: 30
view all 13 authors...
T-cells play an important role in promoting mucosal immunity against pathogens, but the mechanistic basis for their homeostasis in the intestine is still poorly understood. We report here that T-cell-specific deletion of mTOR results in dramatically decreased CD4 and CD8 T-cell numbers in the lamina propria of both small and large intestines under both steady-state and inflammatory conditions. These defects result in defective host resistance against a murine enteropathogen, Citrobacter rodentiu...
1 CitationsSource
#1Hongxia Wang (Southern Medical University)H-Index: 6
#2Joyce S. Cheng (TU: Temple University)H-Index: 1
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 5 authors...
Thymic epithelial cells (TECs) play important roles in T cell generation. Mechanisms that control TEC development and function are still not well defined. The mammalian or mechanistic target of rapamycin complex (mTORC)2 signals to regulate cell survival, nutrient uptake, and metabolism. We report in the present study that mice with TEC-specific ablation of Rictor, a critical and unique adaptor molecule in mTORC2, display thymic atrophy, which accompanies decreased TEC numbers in the medulla. Mo...
6 CitationsSource
#1Hongxia Wang (Southern Medical University)H-Index: 6
#2Yu-Rong Qiu (Southern Medical University)H-Index: 9
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 3 authors...
Promiscuous expression of tissue restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is crucial for negative selection of self-reactive T cells to establish central tolerance. Intercellular transfer of self-peptide-MHC complexes from mTECs to thymic dendritic cells (DCs) allows DCs to acquire TRAs, which in turn contributes to negative selection and regulatory T cell generation. However, mTECs are unlikely to express all TRAs, such as immunoglobulins generated only in B cells...
1 CitationsSource
#1Hongxia Wang (Southern Medical University)H-Index: 6
#2Jinwook Shin (Duke University)H-Index: 18
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 8 authors...
Thymus is crucial for generation of a diverse repertoire of T cells essential for adaptive immunity. Although thymic epithelial cells (TECs) are crucial for thymopoiesis and T cell generation, how TEC development and function are controlled is poorly understood. We report here that mTOR complex 1 (mTORC1) in TECs plays critical roles in thymopoiesis and thymus function. Acute deletion of mTORC1 in adult mice caused severe thymic involution. TEC-specific deficiency of mTORC1 (mTORC1KO) impaired T...
10 CitationsSource
#1Xinxin Ci (Duke University)H-Index: 2
#2Masayuki Kuraoka (Duke University)H-Index: 12
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 11 authors...
Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. We report here that TSC1 differentially regulates mTOR complex 1 (mTORC1) and mTORC2/Akt signaling in B cells. TSC1 deficiency results in the accumulation of transitional-1 (T1) B cells and progressive losses of B cells as they mature beyond the T1 stage. Moreover, TSC1KO mice exhibit a mild defect in the serum anti...
11 CitationsSource
#1Talal Mousallem (Wake Forest University)H-Index: 11
#2Jialong Yang (Duke University)H-Index: 24
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 10 authors...
Identification of the molecular etiologies of primary immunodeficiencies has led to important insights into the development and function of the immune system. We report here the cause of combined immunodeficiency in 4 patients from 2 different consanguineous Qatari families with similar clinical and immunologic phenotypes. The patients presented at an early age with fungal, viral, and bacterial infections and hypogammaglobulinemia. Although their B- and T-cell numbers were normal, they had low r...
30 CitationsSource
#1Sruti Krishna (Duke University)H-Index: 6
#2Jialong Yang (Duke University)H-Index: 24
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 5 authors...
The serine/threonine kinase mammalian/mechanistic target of rapamycin (mTOR) integrates various environmental cues such as the presence of antigen, inflammation, and nutrients to regulate T cell growth, metabolism, and function. The tuberous sclerosis 1 (TSC1)/TSC2 complex negatively regulates the activity of an mTOR-containing multiprotein complex called mTOR complex 1. Recent studies have revealed an essential cell-intrinsic role for TSC1 in T cell survival, quiescence, and mitochondrial homeo...
7 CitationsSource
#1Jinhong WuH-Index: 6
#2Jialong YangH-Index: 24
Last. Xiao-Ping ZhongH-Index: 30
view all 12 authors...
Terminal maturation of invariant NKT (iNKT) cells from stage 2 (CD44+NK1.1–) to stage 3 (CD44+NK1.1+) is accompanied by a functional acquisition of a predominant IFN-γ–producing (iNKT-1) phenotype; however, some cells develop into IL-17–producing iNKT (iNKT-17) cells. iNKT-17 cells are rare and restricted to a CD44+NK1.1– lineage. It is unclear how iNKT terminal maturation is regulated and what factors mediate the predominance of iNKT-1 compared with iNKT-17. The tumor suppressor tuberous sclero...
35 CitationsSource
#1Jinhong Wu (Duke University)H-Index: 6
#2Jinwook Shin (Duke University)H-Index: 18
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 6 authors...
Development of effective immune therapies for cancer patients requires better understanding of hurdles that prevent the generation of effective antitumor immune responses. Administration of α-galactosylceramide (α-GalCer) in animals enhances antitumor immunity via activation of the invariant NKT ( i NKT) cells. However, repeated injections of α-GalCer result in long-term unresponsiveness or anergy of i NKT cells, severely limiting its efficacy in tumor eradication. The mechanisms leading to i NK...
19 CitationsSource
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