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Effects of feline immunodeficiency virus on cognition and behavioral function in cats.

Published on Apr 1, 1999in Journal of Acquired Immune Deficiency Syndromes 3.86
· DOI :10.1097/00042560-199904150-00001
Elizabeth S. Steigerwald1
Estimated H-index: 1
(OSU: Ohio State University),
Martin Sarter66
Estimated H-index: 66
(OSU: Ohio State University)
+ 1 AuthorsMichael Podell20
Estimated H-index: 20
(OSU: Ohio State University)
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  • References (28)
  • Citations (27)
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References28
Newest
Published on Jun 8, 1998
Wayne R. Buck5
Estimated H-index: 5
,
Michael Podell20
Estimated H-index: 20
(OSU: Ohio State University)
Abstract Previously, this laboratory has shown that the Maryland strain of feline immunodeficiency virus (FIV-MD) causes neurological disease in cats similar to human immunodeficiency virus type 1 (HIV-1) in people. Using morphometrical methods on neocortical histologic sections we now show a significant loss of neurons in FIV-MD infected cats compared to age-matched uninfected controls. The neuronal populations affected resembles those lost in HIV-1 infection of the brain in published reports, ...
Published on Sep 1, 1997in AIDS Research and Human Retroviruses 1.80
Rick B. Meeker23
Estimated H-index: 23
,
B.A. Thiede1
Estimated H-index: 1
(UNC: University of North Carolina at Chapel Hill)
+ 2 AuthorsMary B. Tompkins33
Estimated H-index: 33
(UNC: University of North Carolina at Chapel Hill)
Specific pathogen-free cats experimentally infected with feline immunodeficiency virus (FIV) were used to evaluate the development of central nervous system changes during the asymptomatic stages of viral infection. The brains of asyptomatic cats were examined at postinoculation times ranging from 8 weeks to 3 years for changes in neuron density, glutamate receptor density, and synaptophysin immunoreactivity. At 2-3 years postinoculation a small decrease in neuronal density was found in layers 2...
Published on Jan 1, 1997in Journal of NeuroVirology 2.30
Floyd E. Bloom129
Estimated H-index: 129
,
Dianne M Rausch3
Estimated H-index: 3
Published on May 1, 1996in Canadian Journal of Neurological Sciences 2.29
Pim Brouwers43
Estimated H-index: 43
(NIH: National Institutes of Health),
Erich Mohr26
Estimated H-index: 26
(U of O: University of Ottawa)
+ 5 AuthorsP. Pierce1
Estimated H-index: 1
(GUMC: Georgetown University Medical Center)
Background : Neuropsychological studies of the pattern and extent of cognitive impairment in HIV-infected patients have mostly used deviations from control values and/or cut-off scores as criteria for classification of dementia. There is, however, no agreement as to how to define impairment, and classification is imprecise. Method : The current study used a dementia classification matrix, developed with a step-wise linear discriminant analysis of neuropsychological data from patients with primar...
Published on Jan 1, 1996in Annual Review of Neuroscience 12.04
Jonathan D. Glass30
Estimated H-index: 30
(Johns Hopkins University),
R. T. Johnson49
Estimated H-index: 49
Human immunodeficiency virus (HIV) infects the nervous system in the majority of patients, causing a variety of neurological syndromes throughout the course of the disease. This review focuses on the effects of HIV in the central nervous system, with an emphasis on HIV-associated dementia. HIV-associated dementia occurs in a subset of patients with AIDS; it is unclear why these patients and not all patients develop the disease. Several factors are likely to be involved in the pathogenesis of HIV...
Published on May 1, 1995in Canadian Journal of Neurological Sciences 2.29
Christopher Power54
Estimated H-index: 54
(Johns Hopkins University),
R. T. Johnson49
Estimated H-index: 49
(Johns Hopkins University)
HIV-1 infection is characterized by multiple neurological syndromes occuring at all stages of infection. HIV-1-associated dementia, however, is the most devastating CNS consequence of AIDS because of its poor prognosis and functional impairment. A clinical triad of progressive cognitive decline, motor dysfunction, and behavioural abnormalities typifies this subcortical dementia which eventually affects 15 to 20% of AIDS patients. Neuroimaging, CSF studies and neuropsychological testing are frequ...
Published on Apr 1, 1995in Journal of Medical Microbiology 1.93
M. Bennett1
Estimated H-index: 1
(University of Liverpool),
C. A. Hart52
Estimated H-index: 52
(University of Liverpool)
Oscar Prospéro-García23
Estimated H-index: 23
,
Nicole Herold3
Estimated H-index: 3
+ 3 AuthorsSteven J. Henriksen8
Estimated H-index: 8
Human immunodeficiency virus (HIV)-related sleep disturbances have been reported early in AIDS. Likewise, the feline immunodeficiency virus (FIV), a natural lentivirus pathogen of cats, produces a similar immunodeficiency syndrome with neurological sequelae. To identify the neurophysiological substrate of FIV infection in brain, pathogen-free cats were infected with the Maryland strain of FIV. Eight weeks after inoculation, all FIV-infected cats seroconverted and virus was detected in the cerebr...
Published on May 1, 1994in Journal of General Virology 2.81
Tom R. Phillips19
Estimated H-index: 19
,
Oscar Prospéro-García23
Estimated H-index: 23
+ 6 AuthorsJohn H. Elder49
Estimated H-index: 49
Specific pathogen-free cats were infected with the Maryland strain of FIV (FIV-MD) for the purpose of assessing the effects of FIV infection on the central nervous system (CNS). Two separate studies were performed, involving a total of 13 infected cats and six age-matched, sham-inoculated controls. All animals infected with FIV-MD seroconverted by 8 weeks post-infection and virus was recovered from peripheral blood mononuclear cells of all infected cats. All of the infected animals had lower abs...
Cited By27
Newest
Published on Jan 1, 2019in Applied Animal Behaviour Science 1.82
Carly M. Moody1
Estimated H-index: 1
(Ontario Veterinary College),
Georgia J. Mason1
Estimated H-index: 1
(Ontario Agricultural College)
+ 2 AuthorsLee Niel14
Estimated H-index: 14
(Ontario Veterinary College)
Abstract Owned, shelter, and laboratory cats undergo handling and restraint throughout their lifetime for routine health examinations and necessary procedures. Many cats display fear and aggressive behaviour during health examinations, and there is potential for these behaviours to result in incomplete examination, and inadequate diagnosis and treatment, which are cat welfare concerns. Given the lack of validated methods to assess cat responses to restraint, the current study aimed to validate t...
Published on Jul 3, 2018in Viruses 3.81
Claudia Kennedy1
Estimated H-index: 1
,
Andrea Thomson13
Estimated H-index: 13
+ 5 AuthorsMargaret E. Gruen10
Estimated H-index: 10
Environmental enrichment is critical for alleviating stress in laboratory felines. However, there is a paucity of information about suitable enrichment for cats. This study aimed to determine preferred enrichment options of individually-housed, castrated male domestic short hair cats (Felis catus) used in a longitudinal study of the effects of chronic feline immunodeficiency virus (FIV) infection, and to determine if the FIV status of the cats affected enrichment preferences. Preference testing ...
Published on Apr 20, 2018in Viruses 3.81
Craig R. Miller13
Estimated H-index: 13
,
Zaid Abdo1
Estimated H-index: 1
+ 2 AuthorsSue VandeWoude23
Estimated H-index: 23
Feline immunodeficiency virus (FIV) is a naturally-occurring retrovirus that infects domestic and non-domestic feline species, producing progressive immune depletion that results in an acquired immunodeficiency syndrome (AIDS). Much has been learned about FIV since it was first described in 1987, particularly in regard to its application as a model to study the closely related lentivirus, human immunodeficiency virus (HIV). In particular, FIV and HIV share remarkable structure and sequence organ...
Published on Mar 6, 2017in Veterinary Sciences
Rick B. Meeker23
Estimated H-index: 23
,
Lola C. Hudson13
Estimated H-index: 13
Feline Immunodeficiency virus (FIV), similar to its human analog human immunodeficiency virus (HIV), enters the central nervous system (CNS) soon after infection and establishes a protected viral reservoir. The ensuing inflammation and damage give rise to varying degrees of cognitive decline collectively known as HIV-associated neurocognitive disorders (HAND). Because of the similarities to HIV infection and disease, FIV has provided a useful model for both in vitro and in vivo studies of CNS in...
Published on Nov 1, 2015in Animal Cognition 2.49
Kristyn R. Vitale Shreve3
Estimated H-index: 3
(OSU: Oregon State University),
Monique A. R. Udell16
Estimated H-index: 16
(OSU: Oregon State University)
The domestic cat (Felis silvestris catus) has shared an intertwined existence with humans for thousands of years, living on our city streets and in our homes. Yet, little scientific research has focused on the cognition of the domestic cat, especially in comparison with human’s other companion, the domestic dog (Canis lupus familiaris). This review surveys the current status of several areas of cat cognition research including perception, object permanence, memory, physical causality, quantity a...
Barbara L. Sherman13
Estimated H-index: 13
(North Carolina State University College of Veterinary Medicine),
Margaret E. Gruen10
Estimated H-index: 10
(North Carolina State University College of Veterinary Medicine)
+ 5 AuthorsLola C. Hudson13
Estimated H-index: 13
(North Carolina State University College of Veterinary Medicine)
Abstract Few tests have been developed to evaluate the cognitive and motor capabilities of domestic cats, despite the suitability of cats for specific studies of neuroanatomy, infectious diseases, development, aging, and behavior. The present study evaluated a T-maze apparatus as a sensitive and reliable measure of cognition and motor function in cats. Eighteen purpose-bred, specific pathogen-free, male, neutered domestic short-haired cats ( Felis catus ), 1-2 years of age, were trained and test...
Published on Oct 31, 2012in Viruses 3.81
Katrin Hartmann35
Estimated H-index: 35
(LMU: Ludwig Maximilian University of Munich)
Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease. FeLV is more pathogenic, and was long considered to be responsible for more clinical syndromes than any other agent in cats. FeLV can cause tumors (mainly lymphoma), bone marrow suppression syndromes (mainly anemia), and lead to secondary infectious diseases caused by suppressive effects of the virus o...
Published on Jan 1, 2012in Neuroscience & Biobehavioral Reviews 8.00
F. Josef van der Staay11
Estimated H-index: 11
(UU: Utrecht University),
Elise T. Gieling8
Estimated H-index: 8
(UU: Utrecht University)
+ 2 AuthorsFrauke Ohl32
Estimated H-index: 32
(UU: Utrecht University)
Spatial learning and memory tasks have captured a solid position in neuroscience research. A variety of holeboard-type tasks are suitable for investigating the effects of a broad range of experimental manipulations on spatial learning and memory in a broad range of species, including fish, rodents, cats, pigs, tupaias, and humans. We summarize the concepts and procedures underlying tests of spatial discrimination learning, with special emphasis on holeboard-type tasks and task-specific character...
Published on Nov 1, 2011in Veterinary Clinics of North America-small Animal Practice 1.27
Joanna White12
Estimated H-index: 12
(Massey University),
Alison Stickney2
Estimated H-index: 2
(Massey University),
Jacqueline M. Norris20
Estimated H-index: 20
(USYD: University of Sydney)
Since its discovery, feline immunodeficiency virus (FIV) has been the focus of substantial and sustained research efforts, partially in recognition of its potential role as an animal model for human immunodeficiency virus (HIV). Whereas there have een considerable insights into the pathophysiology and immunologic responses to IV infection, important questions remain regarding the impact of FIV infection on an ndividual cat and its likely association with specific disease syndromes.
Published on Oct 1, 2011in Veterinary Immunology and Immunopathology 1.85
Katrin Hartmann35
Estimated H-index: 35
(LMU: Ludwig Maximilian University of Munich)
Abstract Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with a global impact on the health of domestic cats. The two viruses differ in their potential to cause disease. FIV can cause an acquired immunodeficiency syndrome that increases the risk of developing opportunistic infections, neurological diseases, and tumors. In most naturally infected cats, however, FIV itself does not cause severe clinical signs, and FIV-infected cats may live many years without ...