Poster #S30 REVERSE-TRANSLATING BIOLOGICAL MARKERS FOR DISC1-ASSOCIATED BEHAVIORAL DISORDERS TO HUMAN PATIENTS
Abstract
Abnormalities in oligodendrocyte (OLG) differentiation and OLG gene expression deficit have been described in schizophrenia (SZ). Recent studies revealed a critical requirement for Disrupted-in-Schizophrenia 1 (DISC1) in neural development. Transgenic mice with forebrain restricted expression of mutant human DISC1 (ΔhDISC1) are characterized by neuroanatomical and behavioral abnormalities reminiscent of some features of SZ. We sought to...
Paper Details
Title
Poster #S30 REVERSE-TRANSLATING BIOLOGICAL MARKERS FOR DISC1-ASSOCIATED BEHAVIORAL DISORDERS TO HUMAN PATIENTS
Published Date
Apr 1, 2014
Journal
Volume
153
Pages
S99 - S99
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