Original paper
The tandem duplicator phenotype as a distinct genomic configuration in cancer
Abstract
Significance In this study, we provide the first detailed molecular characterization, to our knowledge, of a distinct cancer genomic configuration, the tandem duplicator phenotype (TDP), that is significantly enriched in the molecularly related triple-negative breast, serous ovarian, and endometrial carcinomas. We show here that TDP represents an oncogenic configuration featuring ( i ) genome-wide disruption of cancer genes, ( ii ) loss of cell...
Paper Details
Title
The tandem duplicator phenotype as a distinct genomic configuration in cancer
Published Date
Apr 7, 2016
Volume
113
Issue
17
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Notes
History