0379 Should we take major macro-economic and political developments into account when assessing long-term occupational exposures for epidemiological research?

Summary

We have measured pepsin output in two patients with Zollinger Ellison Syndrome before and after an intravenous dose of cimetidine. Pepsin output increased after H₂ blockade in both patients despite a decrease in both the volume and acidity of secretion. We suggest that nonresponse to cimetidine may be due to increased pepsin secretion when receiving...