Match!

Economic impact of lower-limb osteoarthritis worldwide: a systematic review of cost-of-illness studies

Published on Sep 1, 2016in Osteoarthritis and Cartilage4.879
· DOI :10.1016/j.joca.2016.03.012
Jean-Hugues Salmon3
Estimated H-index: 3
(URCA: University of Reims Champagne-Ardenne),
Anne-Christine Rat18
Estimated H-index: 18
(Paris V: Paris Descartes University)
+ 5 AuthorsBruno Fautrel25
Estimated H-index: 25
(UPMC: Pierre-and-Marie-Curie University)
Abstract
Objective An overview of the economic consequences – overall costs as well as cost breakdown (direct and indirect) – of hip and knee osteoarthritis (OA) worldwide. Methods A systematic literature search of EMBASE, MEDLINE, Scopus and Cochrane databases for articles was performed independently by two rheumatologists who used the same predefined eligible criteria. Papers without abstracts and in languages other than English or French were excluded. Extracted costs were converted to an annual cost and to 2013 euros (€) by using the Consumer Price Index of the relevant countries and the 2013 Purchasing Power Parities between these countries and the European Union average. Results A total of 45 abstracts were selected, and 32 articles were considered for the review. The studied populations were heterogeneous: administrative, hospital and national health survey data. Annual total costs per patient ranged from 0.7 to 12 k€, direct costs per patient from 0.5 to 10.9 k€ and indirect costs per patient from 0.2 to 12.3 k€. The weighted average annual costs per patient living with knee and hip OA were 11.1, 9.5 and 4.4 k€ for total, direct and indirect costs, respectively. Conclusions This review highlights the heterogeneity of studies and lack of methodologic consensus to obtain reliable cost-of-illness estimates for lower-limb OA. However, costs induced by the disease seem substantial and deserve to be more extensively explored.
  • References (65)
  • Citations (33)
📖 Papers frequently viewed together
859 Citations
2 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References65
Newest
#1Alice Courties (French Institute of Health and Medical Research)H-Index: 6
#2Oreste Gualillo (Usach: University of Santiago, Chile)H-Index: 49
Last. Jérémie Sellam (French Institute of Health and Medical Research)H-Index: 33
view all 4 authors...
Osteoarthritis (OA) is a heterogeneous disorder with several risk factors. Among them, obesity has a major impact on both loading and non-loading joints. Mechanical overload and activity of systemic inflammatory mediators derived from adipose tissue (adipokines, free fatty acids, reactive oxygen species) provide clues to the increased incidence and prevalence of OA in obesity. Recently, research found greater OA prevalence and incidence in obese patients with cardiometabolic disturbances than “h...
75 CitationsSource
#1Benedict U. Nwachukwu (HSS: Hospital for Special Surgery)H-Index: 23
#2Kevin J. Bozic (UCSF: University of California, San Francisco)H-Index: 55
Last. Douglas E. PadgettH-Index: 31
view all 7 authors...
Background Total joint arthroplasty (TJA), although considered to be highly beneficial, is associated with substantial costs to the US healthcare system. Cost utility analysis has become an increasingly important means to objectively evaluate the value of a healthcare intervention from the perspective of both extending the quantity and improving the quality of life. Relatively little is known about the overall cost utility analysis evidence base in TJA.
57 CitationsSource
#1Jaume Puig-Junoy (UPF: Pompeu Fabra University)H-Index: 24
#2Alba Ruiz Zamora (UPF: Pompeu Fabra University)H-Index: 1
Abstract Objective The burden of illness that can be attributed to osteoarthritis is considerable and ever increasing. The aim of this systematic review is to analyze currently available data derived from cost-of-illness studies on the healthcare and non-healthcare costs of osteoarthritis. Methods PubMed, Index Medicus Espanol (IME), and the Spanish Database of Health Sciences [ Indice Bibliografico Espanol en Ciencias de la Salud (IBECS)] were searched up to the end of April 2013. This study ad...
46 CitationsSource
#1Caroline BählerH-Index: 3
#2Carola A. HuberH-Index: 12
Last. Oliver ReichH-Index: 11
view all 4 authors...
Chronic conditions and multimorbidity have become one of the main challenges in health care worldwide. However, data on the burden of multimorbidity are still scarce. The purpose of this study is to examine the association between multimorbidity and the health care utilization and costs in the Swiss community-dwelling population, taking into account several sociodemographic factors.
109 CitationsSource
#1P. BertinH-Index: 4
#2François RannouH-Index: 43
Last. C. TaiebH-Index: 4
view all 8 authors...
Objectives: The economic burden of osteoarthritis [OA] has not recently been evaluated in France. This study aimed to provide a health economic update of the patient costs associated with hip or knee OA treated in the community and in medical, surgical and obstetric care [MSO] and post-acute care and rehabilitation [PAC] hospitals in France. Methods: We analyzed data from the Disease Analyzer database of medical records collected by a representative sample of French general practitioners in 2009...
5 CitationsSource
#1Mickaël Hiligsmann (UM: Maastricht University)H-Index: 28
#2Curtis Cooper (University of Oxford)H-Index: 174
Last. Jean-Yves Reginster (University of Liège)H-Index: 92
view all 25 authors...
Abstract Background General recommendations for a reference case for economic studies in rheumatic diseases were published in 2002 in an initiative to improve the comparability of cost-effectiveness studies in the field. Since then, economic evaluations in osteoarthritis (OA) continue to show considerable heterogeneity in methodological approach. Objectives To develop a reference case specific for economic studies in OA, including the standard optimal care, with which to judge new pharmacologic ...
18 CitationsSource
#1Marie Ng (UW: University of Washington)H-Index: 25
#2Thomas R. Fleming (UW: University of Washington)H-Index: 75
Last. Emmanuela Gakidou (UW: University of Washington)H-Index: 45
view all 140 authors...
Summary Background In 2010, overweight and obesity were estimated to cause 3·4 million deaths, 3·9% of years of life lost, and 3·8% of disability-adjusted life-years (DALYs) worldwide. The rise in obesity has led to widespread calls for regular monitoring of changes in overweight and obesity prevalence in all populations. Comparable, up-to-date information about levels and trends is essential to quantify population health effects and to prompt decision makers to prioritise action. We estimate th...
4,312 CitationsSource
#1Emily R. Smith (USYD: University of Sydney)H-Index: 32
#2Damian Hoy (UQ: University of Queensland)H-Index: 53
Last. Lyn March (USYD: University of Sydney)H-Index: 68
view all 8 authors...
Objective To estimate disability from the remainder of musculoskeletal (MSK) disorders (categorised as other MSK) not covered by the estimates made specifically for osteoarthritis (OA), rheumatoid arthritis (RA), gout, low back pain and neck pain, as part of the Global Burden of Disease (GBD) 2010 study. Methods Systematic reviews were conducted to gather the age-sex-specific epidemiological data for other MSK. The focus was on finding health surveys and published studies that measured the overa...
96 CitationsSource
#1Christof Pabinger (Innsbruck Medical University)H-Index: 4
#2H. Lothaller (Medical University of Graz)H-Index: 1
Last. Alexander Geissler (Technical University of Berlin)H-Index: 12
view all 3 authors...
Summary Background Hip arthroplasty and revision surgery is growing exponentially in OECD countries, but rates vary between countries. Methods We extracted economic data and utilization rates data about hip arthroplasty done in OECD countries between 1990 and 2011. Absolute number of implantations and compound annual growth rates were computed per 100,000 population and for patients aged 65 years old and over and for patients aged 64 years and younger. Results In the majority of OECD countries, ...
63 CitationsSource
#1Szilard NemesH-Index: 20
#2Max Gordon (KI: Karolinska Institutet)H-Index: 14
Last. Ola Rolfson (University of Gothenburg)H-Index: 18
view all 4 authors...
Background and purpose — The continuously increasing demand for joint replacement surgery in the past decades imposes higher constraints on the budgets of hospitals and healthcare providers. We undertook an analysis of historical trends in total hip replacement performed in Sweden between 1968 and 2012 in order to provide projections of future demand. Data and methods — We obtained data on total hip replacements registered every year and on the evolution of the Swedish population between 1968 an...
56 CitationsSource
Cited By33
Newest
#1Erik Fink Eriksen (University of Oslo)H-Index: 67
#2Maziar ShabestariH-Index: 4
Last. Philip G. Conaghan (University of Leeds)H-Index: 83
view all 4 authors...
Osteoarthritis (OA) is affecting large proportions of the population worldwide. So far, no effective disease modifying drug has been developed for this disease, limiting the therapeutic options to pain medications, physiotherapy and ultimately surgical approaches, mainly joint implant surgery. In vitro and animal studies have demonstrated that bisphosphonates have the potential to become effective modalities for the treatment of OA. This group of pharmacological agents modulates crucial aspects ...
Source
#2Ewa M. Roos (University of Southern Denmark)H-Index: 65
Last. Jakob KjellbergH-Index: 18
view all 9 authors...
Summary Objective To assess the 24-month cost-effectiveness of supervised treatment compared to written advice in knee osteoarthritis (OA). Design 100 adults with moderate-severe OA not eligible for total knee replacement (TKR) randomized to a 12-week individualized, supervised treatment (exercise, education, diet, insoles and pain medication) or written advice. Effectiveness was measured as change in quality-adjusted life years (QALYs) from baseline to 24 months, including data from baseline, 3...
Source
Abstract Objectives To map the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) onto the EQ-5D-5L in patients with hip or knee osteoarthritis (OA). Methods A prospective observational study was conducted on 758 patients with hip or knee OA who completed the EQ-5D-5L and WOMAC questionnaires, of whom 644 completed them both again 6 months later. Baseline data were used to derive mapping functions. Generalized additive models were used to identify to which powers the WOMAC su...
Source
Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients who can use them. New pharmacological therapies for managing OA are required and a number have been developed targeting different tissues in OA: bone and cartilage, synovium and ne...
Source
#1Jesús Martín Fernández (URJC: King Juan Carlos University)H-Index: 10
#2Roberto García Maroto (Complutense University of Madrid)
view all 11 authors...
Objective Osteoarthritis of the lower limb (OALL) worsens health-related quality of life (HRQL), but this impact has not been quantified with standardized measures. We intend to evaluate the impact of OALL on HRQL through measures based on individual preferences in comparison to the general population. Methods A cross-sectional study was designed. A total of 6234 subjects aged 50 years or older without OALL were selected from the Spanish general population (National Health Survey 2011–12). An op...
Source
#2Ewa M. Roos (University of Southern Denmark)H-Index: 65
Last. Jakob KjellbergH-Index: 18
view all 9 authors...
Objective To assess the 24-month cost-effectiveness of total knee replacement (TKR) plus non-surgical treatment compared with non-surgical treatment with the option of later TKR if needed. Methods 100 adults with moderate-to-severe knee osteoarthritis found eligible for TKR by an orthopaedic surgeon in secondary care were randomised to TKR plus 12 weeks of supervised non-surgical treatment (exercise, education, diet, insoles and pain medication) or to supervised non-surgical treatment alone. Inc...
Source
#1Yingjie Wang (Peking Union Medical College Hospital)H-Index: 2
#2Songpo Shen (Capital Medical University)H-Index: 1
Last. Xisheng Weng (Peking Union Medical College Hospital)H-Index: 15
view all 5 authors...
Objective This study aimed to test the expression and biological function of miR-140-5p in osteoarthritis (OA), and identify its target gene and explore its mechanism in OA.
1 CitationsSource
#1Anthony WrightH-Index: 20
Last. R. WillH-Index: 2
view all 4 authors...
We present a phase 1 study that utilizes a crossover design that provides a rapid and relatively inexpensive methodology for evaluating a new transdermal product. The treatment for osteoarthritis (OA) aims to reduce pain and improve function. An innovative magnetophoresis technology has been developed that facilitates transdermal delivery of ibuprofen. The study used measures that were taken over a relatively short time period to monitor the pharmacodynamic response to ibuprofen. Each participan...
1 CitationsSource
#1A. Dell'Isola (Lund University)
Last. Martin Englund (Lund University)H-Index: 47
view all 12 authors...
Introduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide. Metabolic comorbidities such as type II diabetes occur with a higher rate in people with OA than in the general population. Several factors including obesity, hyperglycaemia toxicity and physical inactivity have been suggested as potential links between diabetes and OA, and have been shown to negatively impact patients’ health and quality of life. However, little is known on the rol...
Source
#1Rana S. Hinman (University of Melbourne)H-Index: 48
#2P.K. Campbell (University of Melbourne)H-Index: 6
Last. Kim L. Bennell (University of Melbourne)H-Index: 80
view all 12 authors...
Objective Evaluate a physiotherapist-led telephone-delivered exercise advice and support intervention for people with knee osteoarthritis. Methods Participant-blinded, assessor-blinded randomised controlled trial. 175 people were randomly allocated to (1) existing telephone service (≥1 nurse consultation for self-management advice) or (2) exercise advice and support (5–10 consultations with a physiotherapist trained in behaviour change for a personalised strengthening and physical activity progr...
1 CitationsSource