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Economic impact of lower-limb osteoarthritis worldwide: a systematic review of cost-of-illness studies

Published on Sep 1, 2016in Osteoarthritis and Cartilage4.88
· DOI :10.1016/j.joca.2016.03.012
Jean-Hugues Salmon3
Estimated H-index: 3
(URCA: University of Reims Champagne-Ardenne),
Anne-Christine Rat17
Estimated H-index: 17
(Paris V: Paris Descartes University)
+ 5 AuthorsB. Fautrel25
Estimated H-index: 25
(UPMC: Pierre-and-Marie-Curie University)
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Abstract
Objective An overview of the economic consequences – overall costs as well as cost breakdown (direct and indirect) – of hip and knee osteoarthritis (OA) worldwide. Methods A systematic literature search of EMBASE, MEDLINE, Scopus and Cochrane databases for articles was performed independently by two rheumatologists who used the same predefined eligible criteria. Papers without abstracts and in languages other than English or French were excluded. Extracted costs were converted to an annual cost and to 2013 euros (€) by using the Consumer Price Index of the relevant countries and the 2013 Purchasing Power Parities between these countries and the European Union average. Results A total of 45 abstracts were selected, and 32 articles were considered for the review. The studied populations were heterogeneous: administrative, hospital and national health survey data. Annual total costs per patient ranged from 0.7 to 12 k€, direct costs per patient from 0.5 to 10.9 k€ and indirect costs per patient from 0.2 to 12.3 k€. The weighted average annual costs per patient living with knee and hip OA were 11.1, 9.5 and 4.4 k€ for total, direct and indirect costs, respectively. Conclusions This review highlights the heterogeneity of studies and lack of methodologic consensus to obtain reliable cost-of-illness estimates for lower-limb OA. However, costs induced by the disease seem substantial and deserve to be more extensively explored.
  • References (65)
  • Citations (26)
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References65
Newest
Published on Dec 1, 2015in BMC Health Services Research1.93
Caroline Bähler3
Estimated H-index: 3
,
Carola A. Huber11
Estimated H-index: 11
+ 1 AuthorsOliver Reich10
Estimated H-index: 10
Chronic conditions and multimorbidity have become one of the main challenges in health care worldwide. However, data on the burden of multimorbidity are still scarce. The purpose of this study is to examine the association between multimorbidity and the health care utilization and costs in the Swiss community-dwelling population, taking into account several sociodemographic factors.
Published on Nov 1, 2015in Osteoarthritis and Cartilage4.88
Alice Courties5
Estimated H-index: 5
(French Institute of Health and Medical Research),
Oreste Gualillo47
Estimated H-index: 47
(Usach: University of Santiago, Chile)
+ 1 AuthorsJ. Sellam22
Estimated H-index: 22
(French Institute of Health and Medical Research)
Osteoarthritis (OA) is a heterogeneous disorder with several risk factors. Among them, obesity has a major impact on both loading and non-loading joints. Mechanical overload and activity of systemic inflammatory mediators derived from adipose tissue (adipokines, free fatty acids, reactive oxygen species) provide clues to the increased incidence and prevalence of OA in obesity. Recently, research found greater OA prevalence and incidence in obese patients with cardiometabolic disturbances than “h...
Published on May 1, 2015in Clinical Orthopaedics and Related Research4.15
Benedict U. Nwachukwu22
Estimated H-index: 22
(HSS: Hospital for Special Surgery),
Kevin J. Bozic53
Estimated H-index: 53
(UCSF: University of California, San Francisco)
+ 4 AuthorsDouglas E. Padgett29
Estimated H-index: 29
Background Total joint arthroplasty (TJA), although considered to be highly beneficial, is associated with substantial costs to the US healthcare system. Cost utility analysis has become an increasingly important means to objectively evaluate the value of a healthcare intervention from the perspective of both extending the quantity and improving the quality of life. Relatively little is known about the overall cost utility analysis evidence base in TJA.
Published on Apr 1, 2015in Seminars in Arthritis and Rheumatism5.07
Jaume Puig-Junoy23
Estimated H-index: 23
(UPF: Pompeu Fabra University),
Alba Ruiz Zamora1
Estimated H-index: 1
(UPF: Pompeu Fabra University)
Abstract Objective The burden of illness that can be attributed to osteoarthritis is considerable and ever increasing. The aim of this systematic review is to analyze currently available data derived from cost-of-illness studies on the healthcare and non-healthcare costs of osteoarthritis. Methods PubMed, Index Medicus Espanol (IME), and the Spanish Database of Health Sciences [ Indice Bibliografico Espanol en Ciencias de la Salud (IBECS)] were searched up to the end of April 2013. This study ad...
Published on Dec 1, 2014in Seminars in Arthritis and Rheumatism5.07
Mickaël Hiligsmann27
Estimated H-index: 27
(UM: Maastricht University),
Curtis Cooper163
Estimated H-index: 163
(University of Oxford)
+ 22 AuthorsJaime Branco24
Estimated H-index: 24
(NOVA: Universidade Nova de Lisboa)
Abstract Background General recommendations for a reference case for economic studies in rheumatic diseases were published in 2002 in an initiative to improve the comparability of cost-effectiveness studies in the field. Since then, economic evaluations in osteoarthritis (OA) continue to show considerable heterogeneity in methodological approach. Objectives To develop a reference case specific for economic studies in OA, including the standard optimal care, with which to judge new pharmacologic ...
Published on Dec 1, 2014in Journal of Musculoskeletal Pain
P. Bertin3
Estimated H-index: 3
,
François Rannou42
Estimated H-index: 42
+ 5 AuthorsC. Taieb3
Estimated H-index: 3
Objectives: The economic burden of osteoarthritis [OA] has not recently been evaluated in France. This study aimed to provide a health economic update of the patient costs associated with hip or knee OA treated in the community and in medical, surgical and obstetric care [MSO] and post-acute care and rehabilitation [PAC] hospitals in France. Methods: We analyzed data from the Disease Analyzer database of medical records collected by a representative sample of French general practitioners in 2009...
Published on Aug 1, 2014in The Lancet59.10
Marie Ng27
Estimated H-index: 27
,
Tom P. Fleming42
Estimated H-index: 42
+ 137 AuthorsSemaw Ferede Abera35
Estimated H-index: 35
(College of Health Sciences, Bahrain)
Summary Background In 2010, overweight and obesity were estimated to cause 3·4 million deaths, 3·9% of years of life lost, and 3·8% of disability-adjusted life-years (DALYs) worldwide. The rise in obesity has led to widespread calls for regular monitoring of changes in overweight and obesity prevalence in all populations. Comparable, up-to-date information about levels and trends is essential to quantify population health effects and to prompt decision makers to prioritise action. We estimate th...
Published on Aug 1, 2014in Annals of the Rheumatic Diseases14.30
Emily R. Smith32
Estimated H-index: 32
(USYD: University of Sydney),
Damian Hoy53
Estimated H-index: 53
(UQ: University of Queensland)
+ 5 AuthorsLyn March68
Estimated H-index: 68
(USYD: University of Sydney)
Objective To estimate disability from the remainder of musculoskeletal (MSK) disorders (categorised as other MSK) not covered by the estimates made specifically for osteoarthritis (OA), rheumatoid arthritis (RA), gout, low back pain and neck pain, as part of the Global Burden of Disease (GBD) 2010 study. Methods Systematic reviews were conducted to gather the age-sex-specific epidemiological data for other MSK. The focus was on finding health surveys and published studies that measured the overa...
Published on Jun 1, 2014in Acta Orthopaedica3.22
Szilard Nemes18
Estimated H-index: 18
,
Max Gordon14
Estimated H-index: 14
(KI: Karolinska Institutet)
+ 1 AuthorsOla Rolfson17
Estimated H-index: 17
(University of Gothenburg)
Background and purpose — The continuously increasing demand for joint replacement surgery in the past decades imposes higher constraints on the budgets of hospitals and healthcare providers. We undertook an analysis of historical trends in total hip replacement performed in Sweden between 1968 and 2012 in order to provide projections of future demand. Data and methods — We obtained data on total hip replacements registered every year and on the evolution of the Swedish population between 1968 an...
Published on Jun 1, 2014in Osteoarthritis and Cartilage4.88
Christof Pabinger4
Estimated H-index: 4
(Innsbruck Medical University),
H. Lothaller1
Estimated H-index: 1
(Medical University of Graz),
Alexander Geissler11
Estimated H-index: 11
(Technical University of Berlin)
Summary Background Hip arthroplasty and revision surgery is growing exponentially in OECD countries, but rates vary between countries. Methods We extracted economic data and utilization rates data about hip arthroplasty done in OECD countries between 1990 and 2011. Absolute number of implantations and compound annual growth rates were computed per 100,000 population and for patients aged 65 years old and over and for patients aged 64 years and younger. Results In the majority of OECD countries, ...
Cited By26
Newest
Published on 2019in BMC Musculoskeletal Disorders2.00
Rachel Nelligan5
Estimated H-index: 5
(University of Melbourne),
Rana S. Hinman47
Estimated H-index: 47
(University of Melbourne)
+ 1 AuthorsKim L. Bennell79
Estimated H-index: 79
(University of Melbourne)
Background Knee osteoarthritis (OA) is a prevalent and chronic condition with no known cure. Exercise is advocated in all clinical guidelines due to its positive effects on symptoms. Despite this, exercise participation is often poor in people with knee OA with access to exercise treatments a known barrier. Internet-delivered exercise interventions have the potential to improve access to evidence-based exercise treatments and can benefit OA outcomes, although non-usage and low adherence potentia...
Published on Dec 1, 2019in BMC Musculoskeletal Disorders2.00
Rachel Nelligan5
Estimated H-index: 5
(University of Melbourne),
Rana S. Hinman47
Estimated H-index: 47
(University of Melbourne)
+ 4 AuthorsKim L. Bennell79
Estimated H-index: 79
(University of Melbourne)
Knee osteoarthritis (OA) is a highly prevalent condition. People with knee OA often have other co-morbidities such as obesity. Exercise is advocated in all clinical guidelines for the management of knee OA. It is often undertaken as a home-based program, initially prescribed by a physiotherapist or other qualified health care provider. However, adherence to home-based exercise is often poor, limiting its ability to meaningfully change clinical symptoms of pain and/or physical function. While the...
Published on May 2, 2019in Stem Cell Research & Therapy4.63
Nádia de Cássia Noronha Nc (USP: University of São Paulo), Nádia de Cássia Noronha (USP: University of São Paulo)+ 5 AuthorsKelen C. R. Malmegrim13
Estimated H-index: 13
(USP: University of São Paulo)
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based therapy of immune-mediated, inflammatory, and degenerative diseases, due to their immunosuppressive, immunomodulatory, and regenerative potentials. Preclinical studies and clinical trials have demonstrated promising therapeutic results although these have been somewhat limited. Aspects such as low in vivo MSC survival in inhospitable disease microenvironments, requirements for ex vivo cell overexpansion prior to...
Gabriele Marchi3
Estimated H-index: 3
(Munich University of Applied Sciences),
Peter Foehr5
Estimated H-index: 5
(TUM: Technische Universität München)
+ 3 AuthorsJohannes Roths4
Estimated H-index: 4
(Munich University of Applied Sciences)
Abstract Objective In this study we aim to show that an optical fiber Bragg grating-based microindentation system, which has the potential to be deployed arthroscopically, can differentiate between healthy and degenerated articular cartilage, which represents an important challenge in minimally-invasive surgery. Design Twenty bovine osteochondral cylinders, extracted from the patellar groove of ten 24 months old animals were subjected to stepwise in vitro stress-relaxation indentation measuremen...
Published on Feb 1, 2019in Seminars in Arthritis and Rheumatism5.07
Gloria María Pontes-Quero (CSIC: Spanish National Research Council), Luis García-Fernández18
Estimated H-index: 18
(CSIC: Spanish National Research Council)
+ 3 AuthorsBlanca Vázquez-Lasa5
Estimated H-index: 5
(CSIC: Spanish National Research Council)
Abstract Objective Osteoarthritis is a chronic, painful and disabling disease which prevalence is increasing in developing countries. Patients with osteoarthritis present a reduced synovial fluid viscoelasticity due to a reduction in concentration and molecular weight of hyaluronic acid. Currently, the main treatment used to restore the compromised rheological properties of synovial fluid is the viscosupplementation by hyaluronic acid injections that can be combined with oral anti-inflammatory d...
Published on Jun 22, 2018in British Journal of Sports Medicine11.64
Alessio Bricca2
Estimated H-index: 2
,
Carsten Bogh Juhl15
Estimated H-index: 15
(UCPH: University of Copenhagen)
+ 2 AuthorsEwa M. Roos63
Estimated H-index: 63
Objective To investigate the impact of knee joint loading exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis (OA) by conducting a systematic review of randomised controlled trials (RCTs). Design We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Data sources We performed a literature search with no restriction on publication year or language in MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Control...
Published on Jul 4, 2019in Quality of Life Research2.49
A.Y. Omorou3
Estimated H-index: 3
(University of Lorraine),
Hamza Achit (University of Lorraine)+ 4 AuthorsFrancis Guillemin (University of Lorraine)
Purpose To examine the respective and combined impact of “hypothetical” functional impairment (FI) and burden of comorbidities accrual on a 5-year risk of health utility (HU) loss in osteoarthritis (OA).
Published on Apr 1, 2019in Osteoarthritis and Cartilage4.88
Anna Cronström3
Estimated H-index: 3
(Lund University),
Leif Dahlberg38
Estimated H-index: 38
(Lund University)
+ 1 AuthorsCatharina Sjödahl Hammarlund8
Estimated H-index: 8
(Lund University)
Summary Objective To explore, using a qualitative approach, reasons for patients’ continued willingness or their shift in willingness for total joint replacement (TJR) surgery, following participation in Joint Academy, a Swedish, digital, non-surgical treatment program for osteoarthritis (OA). Design Nineteen patients with hip or knee OA were interviewed after finishing their first 6 weeks in the treatment program, using a semi-structured interview guide. The interviews were transcribed verbatim...
Published on Mar 1, 2019in Osteoarthritis and Cartilage4.88
Jean-Hugues Salmon3
Estimated H-index: 3
(URCA: University of Reims Champagne-Ardenne),
Anne-Christine Rat17
Estimated H-index: 17
(University of Lorraine)
+ 5 AuthorsBruno Fautrel14
Estimated H-index: 14
(University of Paris)
Summary Background Data on the economic consequences of hip and knee osteoarthritis (OA) are scarce. We aimed to estimate the annual direct and indirect costs for patients followed for hip and/or knee OA in the Knee and Hip Osteoarthritis Long term Assessment (KHOALA) cohort. Methods The KHOALA cohort, set up from 2007 to 2009, is a French multicenter study of 878 individuals with symptomatic knee/hip OA who were 40–75 years old. Resources used were collected annually for 5 years. Costs were ass...
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