Original paper
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
Abstract
Amino acids signal to the mTOR complex I (mTORC1) growth pathway through the Rag GTPases. Multiple distinct complexes regulate the Rags, including GATOR1, a GTPase activating protein (GAP), and GATOR2, a positive regulator of unknown molecular function. Arginine stimulation of cells activates mTORC1, but how it is sensed is not well understood. Recently, SLC38A9 was identified as a putative lysosomal arginine sensor required for arginine to...
Paper Details
Title
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
Published Date
Mar 1, 2016
Journal
Volume
165
Issue
1
Pages
153 - 164
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Notes
History