Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans

Objective Alterations in lipids in muscle and plasma have been documented in insulin‐resistant people with obesity. Whether these lipid alterations are a reflection of insulin resistance or obesity remains unclear. Methods Nondiabetic sedentary individuals not treated with lipid‐lowering medications were studied ( n = 51). Subjects with body mass index (BMI) > 25 kg/m 2 ( n = 28) were stratified based on median glucose infusion rate during a...