Does the γ Polymorph of Glycine Nucleate Faster? A Quantitative Study of Nucleation from Aqueous Solution

We quantitatively study the crystallization of glycine from solution by following the crystallization of a plate with 96 wells, each with 0.1 mL of supersaturated solution. Our first aim is to address the difficult problem of obtaining nucleation data that is reproducible. This problem is difficult because of the extreme sensitivity of nucleation times. Nucleation is sensitive to factors that include how the crystallizing system is prepared and...