Original paper
Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy
Abstract
Serotonin signaling plays key roles in augmentation of pancreatic β-cell function during pregnancy. Increased expression of tryptophan hydroxylase 1 (Tph1), a rate-limiting enzyme for serotonin synthesis by lactogenic hormones, is involved in this phenomenon. To investigate its mechanisms, we here performed 5'-RACE and identified β-cell-specific transcription initiation sites for Tph1. Prolactin enhanced the expression of mRNA containing these...
Paper Details
Title
Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy
Published Date
Jul 1, 2015
Volume
55
Issue
1
Pages
41 - 53
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Notes
History