Obesity Leads to Tissue, but not Serum Vitamin A Deficiency

Obesity negatively affects multiple metabolic pathways, but little is known about the impact of obesity on vitamin A (VA)[retinol (ROL)], a nutrient that regulates expression of genes in numerous pathways essential for human development and health. We demonstrate that obese mice, generated from a high fat diet (HFD) or by genetic mutations (i.e., ob/ob ; db/db ), have greatly reduced ROL levels in multiple organs, including liver, lungs,...