Original paper
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
Abstract
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release. Here we report that the biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by the formation of two disulphide bridges, resulting in an extensive conformational change that...
Paper Details
Title
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
Published Date
Sep 14, 2015
Journal
Volume
6
Issue
1
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Notes
History