Obesity decreases B cell responses in young and elderly individuals

Objective To evaluate the effects of obesity‐associated inflammation on influenza vaccine responses. Methods In young and elderly individuals, both lean and with obesity, antibody responses to influenza vaccination were measured. Results A decrease in in vivo vaccine responses, circulating switched memory, and transitional B cells and an increase in pro‐inflammatory late/exhausted memory B cells were found. In vitro B cell function was measured...