Treatment of Crohn’s Disease with an IgG4-Guided Exclusion Diet: A Randomized Controlled Trial

We previously reported an improvement in symptoms in Crohn’s disease following an IgG4-guided exclusion diet in an open-label study. We aimed to evaluate, in a double-blinded randomized sham-controlled setting, the efficacy of IgG4-guided diet in improving quality of life in patients with Crohn’s disease. Consecutive patients with Crohn’s disease and a Crohn’s disease activity index (CDAI) of 80–400 attending tertiary and secondary care centers...