Match!

Nanostructured materials functionalized with metal complexes: In search of alternatives for administering anticancer metallodrugs

Published on Apr 1, 2016in Coordination Chemistry Reviews13.476
· DOI :10.1016/j.ccr.2016.01.001
Waseem A. Wani18
Estimated H-index: 18
(UTM: Universiti Teknologi Malaysia),
Sanjiv Prashar21
Estimated H-index: 21
(URJC: King Juan Carlos University)
+ 1 AuthorsSantiago Gómez-Ruiz26
Estimated H-index: 26
(URJC: King Juan Carlos University)
Sources
Abstract
Abstract Nanotechnology has shown great promise in unraveling several important issues of conventional anticancer chemotherapy. Expectations project that a new generation of effective cancer therapies will be developed with enormous potential to overcome the biological, biophysical and biomedical obstacles that the human body enacts against standard chemotherapeutic treatments. Generally, nanostructures protect the entombed drug molecules from degradation in blood, allowing their safe and unimpaired delivery to specific target sites in the body. Nanostructured macromolecular systems such as curcubit[ n ]urils, cyclodextrins, liposomes, lipid nanocapsules, proteins, polynuclear organometallic compounds, carbon nanotubes, polymeric nanoparticles and ceramic materials have shown great potential in facilitating the administration of potent anticancer metallodrugs. The uniqueness of these nanostructured materials lies in their suitability for functionalization with small molecule drugs. Recently, there has been a great deal of interest among oncologists and medicinal chemists in functionalizing nanostructured materials with anticancer metallodrugs to ensure better administration. In view of these facts, the state-of-art of nanostructured materials functionalized with metallodrugs as anticancer agents is described in this review. The functionalization of several classes of metal complexes including platinum and non-platinum compounds is also addressed. Special focus is given to the co-delivery of metallodrugs within nanostructures. Toxicity of nanomaterials is discussed and the associated concerns are also highlighted. Finally, the current challenges and the future perspectives of metallodrug functionalization have been commented upon.
  • References (321)
  • Citations (87)
📖 Papers frequently viewed together
359 Citations
53 Citations
42 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References321
Newest
#1Waseem A. Wani (UTM: Universiti Teknologi Malaysia)H-Index: 18
#2Umair Baig (UPM: King Fahd University of Petroleum and Minerals)H-Index: 20
Last. Lee Ting Hun (UTM: Universiti Teknologi Malaysia)H-Index: 5
view all 10 authors...
The revelation of the anticancer properties of cisplatin has inspired research into metal complexes for the treatment of cancer. Several second and third generation cisplatin analogues were developed with claims of good anticancer properties and reduced side effects. However, the persistence of some side effects and the resistance of cancer cells have tempted scientists to explore new metal complexes as anticancer drugs. Therefore, the approach of rational drug design has been extended to the de...
48 CitationsSource
#1Isolda Romero-Canelón (Warw.: University of Warwick)H-Index: 21
#2B. Phoenix (University of Birmingham)H-Index: 3
Last. Nicolas P. E. Barry (Warw.: University of Warwick)H-Index: 26
view all 9 authors...
We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato–carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 core–shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 μM and 0.17 μM, respectively) and cispla...
14 CitationsSource
#1Ileana DragutanH-Index: 20
#2Valerian DragutanH-Index: 19
Last. Albert Demonceau (University of Liège)H-Index: 31
view all 3 authors...
Recent trends in Ru complex chemistry are surveyed with emphasis on the development of anticancer drugs and applications in catalysis, polymers, materials science and nanotechnology.
26 CitationsSource
#1Xiaoyong WangH-Index: 33
#2Xiaohui WangH-Index: 2
Last. Zijian GuoH-Index: 57
view all 3 authors...
ConspectusPlatinum-based anticancer drugs are the mainstay of chemotherapy regimens in clinic. Nevertheless, the efficacy of platinum drugs is badly affected by serious systemic toxicities and drug resistance, and the pharmacokinetics of most platinum drugs is largely unknown. In recent years, a keen interest in functionalizing platinum complexes with bioactive molecules, targeting groups, photosensitizers, fluorophores, or nanomaterials has been sparked among chemical and biomedical researchers...
90 CitationsSource
#1Atsushi Tabata (University of Tokushima)H-Index: 8
#2Yukimasa Ohkubo (University of Tokushima)H-Index: 4
Last. Hideaki Nagamune (University of Tokushima)H-Index: 21
view all 8 authors...
BACKGROUND/AIM: In order to develop an efficient drug-delivery system (DDS), a lipopeptide-loaded liposome that functions as a platform for the transpeptidase reaction mediated by sortase A (SrtA) was constructed and its stability, as well as cell-specific targeting were evaluated in the present study. MATERIALS AND METHODS: Several lipopeptides possessing an acceptor peptide sequence (oligoglycine ≥ three residues) or donor peptide sequence (LPETG) for the SrtA-mediated reaction were chemically...
6 Citations
#1Dena Tila (Tabriz University of Medical Sciences)H-Index: 2
#2Saeed Ghasemi (University of Gilan)H-Index: 5
Last. Saeed Ghanbarzadeh (Tabriz University of Medical Sciences)H-Index: 16
view all 4 authors...
Cancer is considered as one of the most severe health problems and is currently the third most common cause of death in the world after heart and infectious diseases. Novel therapies are constantly being discovered, developed and trialed. Many of the current anticancer agents exhibit non-ideal pharmaceutical and pharmacological properties and are distributed non-specifically throughout the body. This results in death of the both normal healthy and malignant cells and substantially leads to accru...
24 CitationsSource
#1Amir Gharib (IAU: Islamic Azad University)H-Index: 7
#2Zohreh Faezizadeh (IAU: Islamic Azad University)H-Index: 7
Last. Ramin SaravaniH-Index: 8
view all 4 authors...
Background: The combination of artemisinin and transferrin exhibits versatile anticancer activities. In previous, we successfully prepared artemisinin and transferrin-loaded magnetic nanoliposomes and evaluated their anti-proliferative activity against MCF-7 and MDA-MB-231 cell lines in vitro . In this study, we investigate the in vivo anti-breast cancer activity of artemisinin and transferrin-loaded magnetic nanoliposome against breast transplanted tumors in BALB/c mice model. Materials and Met...
7 CitationsSource
#1Matteo Malvezzi (University of Milan)H-Index: 34
#2Paola BertuccioH-Index: 39
Last. E. NegriH-Index: 29
view all 7 authors...
fied by a joinpoint regression model. Results: A total of 1 359 100 cancer deaths are predicted in the EU in 2015 (766 200 men and 592 900 women), corresponding to standardised death rates of 138.4/100 000 men and 83.9/100 000 women, falling 7.5% and 6%, respectively, since 2009. In men, predicted rates for the three major cancers (lung, colorectum and prostate) are lower than in 2009, 20 falling 9%, 5% and 12%. Prostate cancer showed predicted falls of 14%, 17% and 9% in the 35‐64, 65‐74 and 75...
168 CitationsSource
#1Laura Muzi (CNRS: Centre national de la recherche scientifique)H-Index: 4
#2Cécilia Ménard-Moyon (CNRS: Centre national de la recherche scientifique)H-Index: 28
Last. Alberto Bianco (CNRS: Centre national de la recherche scientifique)H-Index: 63
view all 9 authors...
The use of platinum-based chemotherapeutic drugs in cancer therapy still suffers from severe disadvantages, such as lack of appropriate selectivity for tumor tissues and insurgence of multi-drug resistance. Moreover, drug efficacy can be attenuated by several mechanisms such as premature drug inactivation, reduced drug uptake inside cells and increased drug efflux once internalized. The use of functionalized carbon nanotubes (CNTs) as chemotherapeutic drug delivery systems is a promising strateg...
18 CitationsSource
#1Tuo WeiH-Index: 18
#2Chao Chen (CNRS: Centre national de la recherche scientifique)H-Index: 8
Last. Ling Peng (CNRS: Centre national de la recherche scientifique)H-Index: 34
view all 14 authors...
Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope for cancer treatment. In this context, we established an original nanomicellar drug delivery system based on an amphiphilic dendrimer (AmDM), which could generate supramolecular micelles to effectively encapsulate the anticancer drug doxorubicin (DOX) with high drug-loading capacity (>40%), thanks to ...
149 CitationsSource
Cited By87
Newest
#1Gabriela Marinescu (Romanian Academy)H-Index: 16
#2Daniela C. Culita (Romanian Academy)H-Index: 14
Last. Luminita Marutescu (UB: University of Bucharest)H-Index: 8
view all 12 authors...
Abstract Three novel hybrid materials, SBA-15-RuValen, SBA-15-RuValpnol, and SBA-15-RuValdiamci, were obtained by immobilization of new [Ru(L)(PPh3)Cl] complexes (H2L = H2Valen, H2Valpnol, H2Valdiamci, are Schiff base proligands obtained by condensation of o-vanillin with ethylenediamine, 1,3-diamino-2-propanol, and 1,2-diaminocyclohexane, respectively) inside the mesoporous channels of SBA-15. [Ru(Valen)(PPh3)Cl]·3H2O (RuValen), [Ru(Valpnol)(PPh3)Cl]·3H2O (RuValpnol), and [Ru(Valdiamci)(PPh3)Cl...
Source
#1Diana Díaz-García (URJC: King Juan Carlos University)H-Index: 4
#2Lucia SommerovaH-Index: 5
Last. Santiago Gómez-Ruiz (URJC: King Juan Carlos University)H-Index: 26
view all 10 authors...
Abstract Mesoporous silica nanoparticles (MSN) have been functionalized with the polyamino ligand N1-(3-trimethoxysilylpropyl)diethylenetriamine to give the material MSN-DETATMS (M1). The reaction of M1 with the diphenyltin(IV) compound Sn1 [obtained previously from the reaction of (3-glycidyloxypropyl)trimethoxysilane and diphenyltin(IV) dichloride in the presence of two equivalents of sodium hydroxide] in a quantity to obtain a theoretical 10% wt Sn/SiO2, gave the material MSN-DETATMS-O2-SnPh2...
1 CitationsSource
#1Diana Díaz-García (URJC: King Juan Carlos University)H-Index: 4
#2Karla Montalbán-Hernández (URJC: King Juan Carlos University)H-Index: 2
Last. Eva Fischer-FodorH-Index: 13
view all 11 authors...
The synthesis, characterization and cytotoxic activity against different cancer cell lines of various mesoporous silica-based materials containing folate targeting moieties and a cytotoxic fragment based on a triphenyltin(IV) derivative have been studied. Two different mesoporous nanostructured silica systems have been used: firstly, micronic silica particles of the MSU-2 type and, secondly, mesoporous silica nanoparticles (MSNs) of about 80 nm. Both series of materials have been characterized b...
Source
#1Fangman Chen (CAS: Chinese Academy of Sciences)H-Index: 3
#2Fan Zhang (CAS: Chinese Academy of Sciences)H-Index: 21
Last. Yunkun Wu (Fujian Normal University)H-Index: 8
view all 12 authors...
Abstract Ruthenium-based agents are promising in cancer chemotherapy but lack specific targeting and controlled release properties. Herein, a new class of bioreducible mer-[Ru(III)Cl3(dmso)(L)] prodrugs with highly DNA binding affinity were designed and synthesized for nucleus-targeted chemotherapy and selective activation in response to the tumor microenvironment. In this regard, ruthenium(III) prodrugs were reduced into highly active ruthenium(II) drugs in response to high intracellular glutat...
Source
#1Mengjiao Zhou (Nantong University)H-Index: 1
#2Yuqi Xie (Nantong University)H-Index: 1
Last. Feifei An (Xi'an Jiaotong University)H-Index: 14
view all 9 authors...
Hypoxia, a common characteristic in solid tumors, is found in phenotypically aggressive cancers that display resistance to typical cancer interventions. Due to its important role in tumor progression, tumor hypoxia has been considered as a primary target for cancer diagnosis and treatment. An advantage of hypoxia-activated nanomedicines is that they are inactive in normoxic cells. In hypoxic tumor tissues and cells, these nanomedicines undergo reduction by activated enzymes (usually through 1 or...
1 CitationsSource
#1Iftikhar AhmadH-Index: 28
#1Iftikhar Ahmad (QAU: Quaid-i-Azam University)H-Index: 5
Last. Saira TabassumH-Index: 8
view all 10 authors...
Abstract Four new triorganotin(IV) amide based carboxylates of general formula R3SnL1and R3SnL2, where R = Me(1,3) and n-butyl (2,4), and L1= (Z)-4-(p-methoxyphenylamino)-4-oxo-2-butenoic acid (HL1) L2 = (Z)-4-(3,5-bis(trifluoromethyl)phenylamino)-4-oxo-2-butenoic acid (HL2) have been synthesized by refluxing methanolic solution of organtin(IV) chloride and ligand (1:1 M ratio). The synthesized compounds were characterized by FT-IR, elemental analysis, NMR (1H, 13C, 119Sn &19F) and single crysta...
Source
#1Patrizia Rossi (UniFI: University of Florence)H-Index: 21
#2Eleonora Macedi (University of Urbino)H-Index: 10
Last. Vieri Fusi (University of Urbino)H-Index: 28
view all 6 authors...
The hetero-tetranuclear Cu2+ /Ca2+ /Ca2+ /Cu2+ complex obtained with the N,N'-bis((3-hydroxy-4-pyron-2-yl)methyl)-N,N'-dimethylethylendiamine (Malten) ligand has been studied in solid and solution states as scaffold to bind anions. Three crystal structures showing the same metal ions sequence have been examined; they display a tetracharged complex cation neutralized by four monocharged anions. The anions play two different roles: as coordinated (two ClO4- , Cl- or NO3- ) or ancillary (two ClO4- ...
Source
#1Kamila W. Domagala (AGH University of Science and Technology)H-Index: 2
#2C. Jacquin (Eawag: Swiss Federal Institute of Aquatic Science and Technology)
Last. Thomas Graule (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 41
view all 7 authors...
Abstract Both multi-walled carbon nanotubes (MWCNTs) and metal or metal oxides have demonstrated virus removal efficacy in drinking water applications. In this study, MWCNTs were coated with copper(I) oxide (Cu2O) using three distinct synthesis procedures (copper ion attachment, copper hydroxide precipitation, and [Cu(NH3)4]2+ complex attachment) and virus removal efficacy (using MS2 bacteriophages) was evaluated. All synthesis procedures resulted in the presence of adsorbed, nanosized Cu2O part...
Source
#1Soroush Soltani (UPM: Universiti Putra Malaysia)H-Index: 7
#2Nasrin Khanian (IAU: Islamic Azad University)H-Index: 2
Last. Thomas Shean Yaw Choong (UPM: Universiti Putra Malaysia)H-Index: 25
view all 4 authors...
Since 1990 and the invention of the very first generation of ordered mesoporous silica materials, several innovative methodologies have been applied to synthesize, characterize, and modify silica/non-silica mesoporous materials. The growth of the mesoporous materials field has generated significant environmental and economic advantages compared to various other industrial developments. According to the literature, there are several key synthesis approaches and parameters that can affect the stru...
Source
#1Anup Paul (IST: Instituto Superior Técnico)H-Index: 16
#1Anup Paul (University of Lisbon)
Last. Armando J. L. Pombeiro (IST: Instituto Superior Técnico)H-Index: 64
view all 4 authors...
Source