Insights about weight loss-induced metabolic adaptation

Weight loss-induced metabolic adaptation refers to the decrease in thermogenesis to an extent greater than predicted based on the change in body weight and composition (1) (Figure 1). Teleologically, this phenomenon might arise as a way to reduce the gap between energy intake and expenditure, so further weight loss is prevented and chance of survival is enhanced. Such adaptation could be of benefit in times of famine; however, in an obesogenic...