Review paper
Bispecific antibodies and their applications
Abstract
Bispecific antibodies (BsAbs) recognize two different epitopes. This dual specificity opens up a wide range of applications, including redirecting T cells to tumor cells, blocking two different signaling pathways simultaneously, dual targeting of different disease mediators, and delivering payloads to targeted sites. The approval of catumaxomab (anti-EpCAM and anti-CD3) and blinatumomab (anti-CD19 and anti-CD3) has become a major milestone in...
Paper Details
Title
Bispecific antibodies and their applications
Published Date
Dec 1, 2015
Volume
8
Issue
1
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