Green tea extract provides extensive Nrf2‐independent protection against lipid accumulation and NFκB pro‐ inflammatory responses during nonalcoholic steatohepatitis in mice fed a high‐fat diet

Scope Green tea extract (GTE) reduces liver steatosis and inflammation during nonalcoholic steatohepatitis (NASH). We hypothesized GTE would mitigate NASH in a nuclear factor erythroid‐2‐related‐factor‐2 (Nrf2)‐dependent manner in a high fat (HF) induced model. Methods and results Nrf2‐null and wild‐type (WT) mice were fed an HF diet containing 0 or 2% GTE for eight weeks prior to assessing parameters of NASH. Compared to WT mice, Nrf2‐null mice...