Mechanics and Single-Molecule Interrogation of DNA Recombination
Abstract
The repair of DNA by homologous recombination is an essential, efficient, and high-fidelity process that mends DNA lesions formed during cellular metabolism; these lesions include double-stranded DNA breaks, daughter-strand gaps, and DNA cross-links. Genetic defects in the homologous recombination pathway undermine genomic integrity and cause the accumulation of gross chromosomal abnormalities—including rearrangements, deletions, and...
Paper Details
Title
Mechanics and Single-Molecule Interrogation of DNA Recombination
Published Date
Jun 2, 2016
Volume
85
Issue
1
Pages
193 - 226
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