Chemistry

Drug

Viscosity

Dosage form

Matrix (chemical analysis)

Diclofenac Sodium

Drug delivery

Medicine

Organic chemistry

Materials science

Composite material

Chromatography

Pharmacology

PURPOSE: The present work reports an attempt was to formulate matrix systems for oral sustained release drug delivery systems using diverse grades of hydroxypropyl methylcellulose (Methocel K4M, K15M, K100M and K100LV), in order to investigate the effect of various grades of these polymer on release mechanism from matrix tablets. Diclofenac Sodium was used as a model drug to evaluate its release characteristics from different matrices. METHODS: HPMC matrix tablets of Diclofenac Sodium using HPMC (methocel K100LV K4M, K15M, K100M CR) lactose were prepared by direct compression process. The USP paddle method was selected to perform the dissolution profiles carried out by USP apparatus 2 (paddle) at 50 rpm in 900 ml 0.1 N HCl, and phosphate buffer. Drug release was analyzed according to their kinetic models. A One way analysis of variance (ANOVA) was used to interpret the result. RESULTS: Statistically significant differences were found among the drug release profile from different matrices. At a fixed polymer l...

Evaluation of Various Grades of Hydroxypropylmethylcellulose Matrix Systems as Oral Sustained Release Drug Delivery systems